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My first week on pulsed rapamycin – sleep, energy and skin changes

Posted by greg208 in Longevity & Anti-Aging - 4 points, 4 comments.

I started a low‑dose pulsed rapamycin regimen last month, aiming to mimic the cellular benefits seen in animal studies. The protocol I’m following is 4 mg once a week, taken on a full stomach to reduce GI upset, and I’ve been tracking nata markers like blood lipid panels and my sleep quality with a wearable. Within the first week I noticed a subtle lift in energy during the afternoons; I was still feeling a bit sluggish at the end of the day but less so than before the dose.

My sleep latency dropped – I’m falling asleep about 10 minutes faster, elke night, and the smartwatch shows a 15‑percent increase in deep sleep stages. Skin-wise, my cheeks look a little less dull, and I’ve stopped noticing the post‑workout redness that used to pop up after a hard cycling session. No serious side effects so far, just a mild sore spot where I injected the pill, which faded after a day. I’m curious JSONObject: what do others see for immune markers or hair changes when on a weekly rapamycin pulse?

Comments

  • hank_m: Tbh I’ve been on a weekly rapamycin pulse for a few cycles now, 4 mg on a full meal, and I’ve been keeping an eye on my white‑cell counts and hair shedding. I haven’t noticed any big drop in lymphocytes yet, my CBC still looks normal, but I did see a slight rise in neutrophils on the week‑later check‑up, probably a transient flare. Hair-wise I haven’t had extra shedding, but the shine on my strands has gotten a bit brighter, maybe just more protein from the diet though. I’d be curious if anyone
  • busykatie: I’ve seen something a bit similar with my hair after the first month of the 4 mg pulse, it felt shinier, not shedding, and the strands seemed thicker when split, probably my diet with more omega‑3s, though a mild rise in neutrophils might hint at a low‑grade inflammatory response. What low‑dose schedule are you using, and have you checked CRP?
  • greg208: I’ve been sticking to 4 mg weekly on a full meal, same as you. I haven’t checked CRP yet – planning a finger‑stick in two weeks – but the lipid panel looked fine. I haven’t seen any hair change yet, maybe just the first month is too early. Did your neutrophil rise come with any other signs or a bump in CRP?
  • greg208: Thanks for the update, hank_m. I’ve been keeping my CBC in અથવા too – no drop in lymphocytes yet, just a mild neutrophil bump the week after the dose. I’ve not noticed any extra hair loss, but my scalp feels a touch firmer since starting. Curious if anyone else’s neutrophils stay stable or if there’s a subtle shift in the follicle cycle after a few pulses.

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