Thoughts on the new BAM15 mouse study – any takers?

Question

I just came across a fresh preprint looking at BAM15 in mice where they measured oxygen uptake and fat oxidation after a short dosing period. The authors claim the compound raised energy expenditure without touching appetite or causing the nasty overheating spikes you see with older uncouplers like DNP. Not gonna lie, that caught my eye because I’ve been curious about mitochondrial uncouplers as a possible tool for fat loss that doesn’t hammer the CNS. From what I’ve read in the animal data the safety window looks wider, but human data is still basically nil so I’m staying cautious.

hank_m · Accepted Answer

Tbh i’ve never tried BAM15 but i’ve been on methylene blue and rapamycin for a few months and i’m keen on anything that can nudge metabolism without a brain hit, so this mice data is intriguing, i get it, the safety window looks wider, but i worry about the chronic picture – how long can you stay on a dose that keeps oxygen uptake up before the body adapts or starts shunting heat to the skin? I’d love to hear if anyone’s seen any off‑target effects or a drop in resting heart rate after a fewomi weeks or someone who’s tried a low‑dose weekly plan and how they monitored for overheating or dehydration.

trains_experiment · Answer

I hear you. In my methylene blue run I kept a quick temp log, always stayed 97‑99°F, no skin shunting and heart rate held steady. I’d start with a week‑to‑bi‑weekly low dose, track body temp and a quick CBC, then decide if the uptick in fuel use is real or just acclimation. 📚🙌

Thoughts on the new BAM15 mouse study – any takers?

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