Thoughts on the new BAM15 mouse study – any takers?

Posted by greg208 in Research & News - 6 points, 8 comments.

I just came across a fresh preprint looking at BAM15 in mice where they measured oxygen uptake and fat oxidation after a short dosing period. The authors claim the compound raised energy expenditure without touching appetite or causing the nasty overheating spikes you see with older uncouplers like DNP. Not gonna lie, that caught my eye because I’ve been curious about mitochondrial uncouplers as a possible tool for fat loss that doesn’t hammer the CNS. From what I’ve read in the animal data the safety window looks wider, but human data is still basically nil so I’m staying cautious.

Comments

• hank_m: Tbh i’ve never tried BAM15 but i’ve been on methylene blue and rapamycin for a few months and i’m keen on anything that can nudge metabolism without a brain hit, so this mice data is intriguing, i get it, the safety window looks wider, but i worry about the chronic picture – how long can you stay on a dose that keeps oxygen uptake up before the body adapts or starts shunting heat to the skin? I’d love to hear if anyone’s seen any off‑target effects or a drop in resting heart rate after a fewomi
• trains_experiment: I hear you. In my methylene blue run I kept a quick temp log, always stayed 97‑99°F, no skin shunting and heart rate held steady. I’d start with a week‑to‑bi‑weekly low dose, track body temp and a quick CBC, then decide if the uptick in fuel use is real or just acclimation. 📚🙌
• aspiring_trailrun: I haven’t tried BAM15 yet, but the concept of a mild uncoupler that lifts basal metabolism without the CNS hits that DNP had gives me a glimmer of hope. In my own training I’ve used low‑ turística peptides that seemed to boost energy on hard sessions, and I’ve always tracked heart rate and core temperature to stay safe. If anyone starts a human trial or has early anecdotal data, let me know – the safety window is the real question for us.
• greg208: Thanks for the reply. 5 °C in mice. I’m planning a low‑dose start and will log HR, core temp and any sweat response. Do you have a specific target range you monitor during tough runs? Knowing what worked for you with your peptides would help me fine‑tune my own safety window.
• greg208: Thanks for the solid outline. I’ll keep a temp log in the same range – 97‑99°F – and monitor heart rate. When I start a low dose I’ll aim for a week and then a second week, just like you. About the CBC – which markers are most useful for spotting any early mitochondrial stress? 1 mg/kg would be a sensible starting point for a human?
• greg208: I’m not on BAM15 yet, so no personal data, but the mouse paper showed a steady rise in V˙O₂ for about 4–6 weeks before they started tapering the dose to keep it safe. No obvious drop in resting heart rate was noted in the mice. In a human trial you’d want to log skin‑surface temp every 3‑4 hours and keep a daily hydration log, maybe a smartwatch for heart‑rate trends. Do you already track skin temp or use a waterproof thermometer?
• hank_m: Hey, i’vent used bam15 yet either – i’ve only been following the mouse papers and a few vlogs from other biohackers, so it’s all still theoretical on my end, tbh. I would be cautious and stick to core temperature and HR monitoring like you do, because the safety window is still december‑weather‑wide, and i don’t want to gamble with an uncoupler that could spike metabolism like dnp. Let me know if anyone else gets a chance to try it in humans.
• greg208: 5 °C or HR above 140 bpm. Not gonna lie, it’s a bit of extra effort, but the safety feels worth it. Do you keep an eye on anything else, like body‑weight or blood markers? I’d love to hear if anyone else has a protocol that’s worked in practice, just to cross‑check what the mice data is hinting at.

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