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How weekly rapamycin changed my energy and sleep after 6 weeks

Posted by greg208 in Longevity & Anti-Aging - 1 points, 4 comments.

Not gonna lie, I started a low‑dose rapamycin protocol, 6 mg once a week, after hearing about its autophagy effects and immune boosting. After the first week, my morning lift was better – I could get up without that groggy fog that used to cling to me. By week three, my sleep quality improved; I fell asleep faster and woke up feeling refreshed, not like a broken clock.

Over the next three weeks the energy boost stuck – zasch I could finish a brisk 5‑k training run without feeling winded. The downside? 1 – not huge but worth monitoring.

I’ve been looking at a low‑dose metformin combo to balance that. Anyone else noticing sleep or energy changes with a weekly rapamycin pulse? Also curious if anyone’s seen a jump in appetite or weight gain – I’ve stayed steady, but might miss something.

Comments

  • aspiring_trailrun: I’ve been on a similar 6 mg‑per‑week rapamycin course for about eight weeks now. My mornings feel a bit crisper, but I noticed a slight increase in late‑evening cravings that didn’t translate into weight gain – maybe a shift in my circadian appetite. Sleep quality has improved, though a few nights I had trouble falling asleep right after dosing; I found that moving the injection to the middle of the week rather than the start helped. I’m keeping an eye on my renal markers and glucose because ra
  • greg208: Hey, I’ve found something similar – after my first couple weeks the dose in the morning did lift me, but I noticed a slight dip in sleep a couple of nights after injection. I’m thinking of moving it to the middle of the week like you suggested. How did your glucose trend look over time? Also what renal markers are you checking and what numbers are you seeing?
  • liam_sleepnerd: Tbh I’ve also slipped the 6 mg from Monday to Wednesday in my eight‑week run, and the late‑evening cravings just faded. I started logging glucose every morning and saw a smoother spike. Maybe the mid‑week dose keeps your circadian rhythm less rattled. How’s your HRV looking?
  • greg208: Not gonna lie, I’ve stuck to Monday only so far so HRV was a bit variable – I only printed a couple of readings and they were in the 60‑70 range. I’ll try the mid‑week dose like you and log HRV after each session to see if the rhythm steadies. Do you notice any changes in heart‑rate on the days right after the dose?

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