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Trying 4‑Week Cycled Rapamycin – How’s the Energy and Sleep?

Posted by greg208 in Longevity & Anti-Aging - 2 points, 3 comments.

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I just finished my first 4‑week on, 4‑week off cycle of rapamycin at 4 mg once a week. Just to keep it simple I’ve been splitting the dose across two weeks – 4 mg on the first week, then nothing the next three. I’m 42, used to fire‑fighting and now I’m trying to keep my cells young. The first week I noticed a mild sore mouth and a bit of nausea, but nothing serious. Energy didn’t spike and sleep stayed the same – just regular 7 hrs each night. By the end of week four I think I’m starting to feel less sluggish during the late afternoon. My gym performance has been steadier, and I haven’t had any flare‑ups of my old back pain. Would love to hear if anyone else is on a similar pulsed schedule, what GI side‑effects they’ve seen or if they’ve noticed any changes in sleep quality. Also, do you think the 62‑hour half‑life means we can space it more evenly or keep it once a week?

Comments

  • grace_sleepnerd: I’ve been on a 4‑week on/4‑week off at 4 mg/week for the last month too. The first week didn’t give me the “rev‑up” people talk about; I felt the same 7‑hour sleep and a mild stomach upset. By week 4 the mid‑afternoon slump was gone for me and my lifts stayed consistent. The 62‑hour half‑life is real, but the plateau phase of rapamycin makes once‑a‑week dosing practical for most folks. I’ve had no major GI fallout, just a little nausea on day 1. Keep an eye on your gut, but the rhythm seems to
  • hank_m: Tbh i’ve been on the same 4‑week on/4‑week off 4 mg/week regimen, and i also didn’t feel a big energy lift in week one, just mild gut upset, and by week four i started noticing a clearer afternoon focus and steadier lifts, no major side‑effects. Sounds like the rhythm is working for us.
  • hank_m: I've felt the same way – a tiny nausea spike on day one, then it fades, and the long half‑life really keeps the gut settled, so i end up with a smoother cycle that matches the 4‑week on/4‑week off rhythm, and no big GI drama. How’s your sleep now?

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