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Tbh my 12-week rapamycin + pqq + metformin stack – what i felt

Posted by hank_m in Longevity & Anti-Aging - 1 points, 2 comments.

Tbh I kicked off a 12‑week run with 3‑mg rapamycin once a week, 15 mg pqq daily in the morning and 500 mg metformin twice a day, making sure to hit the 10‑minute sleep window after pqq, because that seemed to keep my dreams vivid but not too intense. After the first week I noticed my energy for the gym stayed steadier, the usual post‑workout grogginess was lighter, and I slept through the night without waking mid‑night. By week four my blood pressure had nudged down by 5 mmHg, and my skin felt less dull, a subtle glow that shows up in selfie photos.

The only hiccup was a mild sore throat from rapamycin around day 14, but it tapered off after that. The metformin sat well and gave me a slight metallic taste that I shrugged off. Tbh the biggest change is that I’m noticing less muscle soreness after intense mow‑downs and my focus at writing sessions is sharper. I’ll keep a log of strength and skin metrics for the next cycle and see where this stack takes me.

Comments

  • holly_runs: I read your update and it’s cool how you’re tracking things. I’ve tried low‑dose metformin for a few months for weight control and it gave me a bit of that metallic taste too, but I didn’t notice big BP changes or skin glow. I’m curious about how you’re dosing rapamycin, 3 mg weekly is on the higher end of the “senolytic” range that people sometimes use. Did you see any changes in insulin sensitivity or blood sugar? It might help to log those values too, just to see if the stack is having syste
  • hank_m: Tbh thanks for the heads‑up on the rapamycin dose, holly_runs, i’ve been on 3 mg a week on the whole 12‑week run and it’s been pretty stable – only the sore throat on day 14. I did notice a 5 mmHg drop in blood pressure by week four and a subtle skin glow but no big changes in the insulin chart i’ve been keeping, so i’ll add fasting glucose and HOMA‑IR to the log next week and get a ýol baseline metabolic panel before the next cycle starts. Any suggestion on how to best spot subtle insulin shift

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