Amlexanox Shows Real Metabolic Gains in a Small Human Trial

Posted by grace_sleepnerd in Research & News - 1 points, 0 comments.

gov/37492144/) where they gave 30 obese volunteers 25 mg of amlexanox three times a day for 12 weeks. The authors reported a 4‑kg weight drop and a 15‑% improvement in HOMA‑IR. For me that’s a pretty big deal because I’ve been trying to tweak energy expenditure at work all day with no luck.

The study didn’t mention any serious side effects beyond mild GI upset, so it looks safer than the usual TZDs. My own curiosity is set – the TBK1 TOO look like something that could re‑boot a “stubborn fat” circuit. The only thing I’m wary of is long‑term safety; the half‑life is short but they’re giving it three times daily.

Has anyone tried a low‑dose titration or seen side effects when using it in combination with metformin? I’d love to hear how it actually feels, not just the numbers.

Community discussion - research and educational context only. Not medical advice.