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Low dose rapamycin – my first 3‑week cycle, sleep, energy and side effects

Posted by greg208 in Longevity & Anti-Aging - 1 points, 3 comments.

I started a low‑dose rapamycin cycle last month, 4 mg once a week, as the telemedicine clinic suggested for an anti‑aging protocol. I took it on a Sunday evening, before the weekend unwind, and was hoping for a mild boost in autophagy without the heavy side effects. The first week I noticed my sleep a bit more restful; I fell asleep quicker and woke up feeling less groggy, but then the next day I felt a subtle stiffness in my joints that I usually get after a long shift.

By week two, the stiffness faded, but I did notice a dry mouth and a mild sore throat that lasted about 48 hours. Energy-wise, I felt a quieter, steadier pulse throughout the day – not a crash, but not a high‑energy sprint either. A couple of nights I had a bit of insomnia, probably because I took it close to bedtime – maybe I should try a lighter dose or shift the timing. Overall, it’s a manageable experience so far, and I’m keen to see if the benefits hold over a longer run.

Comments

  • aspiring_trailrun: I’ve been on a 4 mg weekly regime for three weeks myself. The first day or two it felt similar to you – a subtle stiffness that ebbed after a short walk, and a dry mouth that resolved by the third day. I found that taking it earlier in the evening, maybe after dinner, helped with the insomnia bit. Also, a glass of water before the pill seemed to ease the dry mouth a touch. I’ve noticed my energy has stayed even, not the high‑sprint type, but steady enough for my runs. It would be good to hear i
  • greg208: Nice to hear you’re on the same blood‑pressure‑low 4 mg schedule, mate. I copied you on the earlier‑evening timing after dinner and that glass of water and it did ease the dry‑mouth a touch, though the first dose still made my throat feel a bit scratchy for a day. I did notice a small dip in appetite the week after the first dose – a few more carbs at breakfast didn’t help. Will I see a repeat dry‑mouth on the next dose or will the water trick hold?
  • liam_sleepnerd: Sounds like a hit‑and‑miss pattern. I’ve had the dry mouth pop back whenever I reset the dose, so timing is key, taking it right after dinner tends to keep it at bay. Appetite for me’s been pretty flat; no surge or slump, just the usual noon slump. Did you notice any shift in hunger curves after the first dose?

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