RU-58841 Scalp Irritation: Thoughts on Safe Use?

Posted by grace_sleepnerd in Safety & Side Effects - 1 points, 0 comments.

Hi all, I've been dabbling with RU‑58841 as a topical anti‑androgen to treat my hair loss. I started with a 50 mg/mL solution, applied it once a day to my vertex. Within a week I noticed itching, a mild burning sensation, and a faint redness that lingered for a couple of hours.

I paused for a day, then re‑started with a diluted 25 mg/mL mix in a mild carrier oil. The irritation subsided, but I still get occasional dry patches after a week of daily use. I'm wondering if anyone has a more stable vehicle or a recommended patch‑test routine before full‑head application.

Also, does the dermatitis risk increase after prolonged use? I’ve read that RU‑58841 is non‑steroidal and should have minimal systemic effects, but I’ve seen a few reports of contact dermatitis in forums. I’d like to know if using a fragrance‑free emollient and sticking to a 7‑day cycle helps.

Any insights on long‑term safety, or ways to keep the scalp from drying out while still getting the benefit? Thanks.

Community discussion - research and educational context only. Not medical advice.