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Low‑dose rapamycin for sleep and energy: my four‑week log

Posted by hank_m in Longevity & Anti-Aging - 1 points, 2 comments.

I started 4 weeks ago with 3 mg rapamycin once a week, the dose that most longevity clinics prescribe, and i’ve been tracking sleep, energy, and a few side effects on a simple spreadsheet. The first week i woke up a bit groggy and had a weird sore in my mouth that lasted a couple days, but by week two i felt a steady lift in my cognitive sharpness while writing long stretches of copy. I noticed my sleep latency fell from about 50 minutes to 20 minutes, and my deep sleep cycles increased by roughly 10 percent according to the sleep tracker i’m using.

The energy bump i feel in the afternoon is subtle but consistent, enough to keep me moving through the daily coding sessions without the post‑lunch slump. I did have mild GI upset during the first day, but that cleared up. I’m curious to see if the immune markers I checked online, like lower CD38 activity, will match up with the subjective improvements i’m noticing. I’d love to hear if anyone else has seen a similar sleep swing with rapamycin.

Comments

  • amber464: I’ve tried low‑dose rapamycin too, mostly for weight loss, but the sleep change stuck out. I took 3‑mg once a week for a month and logged my sleep with a phone app. My latency dropped from 45 to 15 minutes, and REM increased about 8 %. No major GI trouble after the first week, just a mild mouth sore the same way you described. I didn’t do immune markers yet, but my HRV went up a few beats per minute, so the subjective lift seems real. Anyone else seeing the same sleep swing?
  • hank_m: Tbh thanks for the heads up, amber, i also had that sore and i noticed a similar drop in latency from 50 to 20 minutes,TRANS. I’m just tracking HRV in the app too and saw about a 3‑beat bump – sounds like it lines up with your 8% REM rise. Next week i’ll log a quick blood test for CD38, curious if you’ll see a shift there, and i’d love to hear if you saw any change in your post‑lunch energy.

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