ResearchSafe

Scalp irritation and dryness after starting RU‑58841 daily

Posted by vik595 in Safety & Side Effects - 1 points, 4 comments.

5 mL to the crown each morning. The hair loss seemed to slow down after the second week, but by day 12 I started noticing a flaky, itchy patch where I’d applied the most. It felt dry and a bit burning, especially after I showered and let the water run over the scalp.

I tried diluting the solution to 50 mg/mL and cutting the dose in half, but the irritation persisted, though it’s less intense. I’ve been tracking my skin’s response in a journal and also measured my resting heart rate and HRV; no systemic changes so far. Has anyone else seen similar scalp dryness with RU‑58841?

Any tips on carrier vehicles, moisturizers, or timing that helped reduce the irritation? I’m keen to keep using it for hair growth but want to avoid worsening dermatitis.

Comments

  • trevor_recovery: I’ve been using RU‑58841 for about six weeks and hit the same flare around week two. My scalp got pretty tight and flaky, especially after hot showers. What helped me was switching the carrier to a propylene‑glycol‑free base like a light silicone serum; it felt less stingy and didn’t dry out the skin as much. I also started applying a thin layer of hypoallergenic moisturizer (a simple ceramide cream) about 30 minutes after the RU‑58841 dried, and I kept the water temperature lukewarm. The irrit
  • vik595: That lines up with what I’m seeing – the hot shower definitely amps up the tightness. I switched to a silicone‑based carrier last week and added a light ceramide lotion after the drop dries, plus I’m using lukewarm water. The flakiness dropped within three days. How long did it take for yours to settle?
  • aspiring_trailrun: I’ve actually tried the silicone‑based carrier too and found it much gentler – the sting went down within a few days. I’ll give the ceramide cream a go after it dries. Have you noticed any difference in how quickly the hair‑loss slowdown appears with the gentler base?
  • vik595: That silicone carrier felt noticeably smoother on my scalp too – the burning eased after about three days. I didn’t see a big jump in the slowdown; the hair‑loss plateau still hit around day 10, same as with the original base. I’ll try the ceramide after it dries and see if the flakiness drops further. If it does, I’ll log the change and let you know.

Community discussion - research and educational context only. Not medical advice.