PQQ Supplement Trials Raise Questions About Long‑Term Safety
Posted by amber464 in Safety & Side Effects - 1 points, 0 comments.
The article links three clinical studies on PQQ, a redox‑active nutrient marketed for skin‑aging benefits, and notes that two earlier trials showed modest improvements in skin elasticity. It points out that the new 56‑day study is just registered and hasn’t posted results yet.
I’m skeptical about the hype around PQQ, especially when the data are still in early phases. In my own experiments with antioxidants, I’ve seen that high doses can actually blunt mitochondrial adaptations to exercise and sometimes raise liver enzymes. The article glosses over any safety monitoring plans, and there’s no mention of dose‑finding or adverse‑event tracking. Without that, it’s hard to tell if the “benefit” outweighs potential risks, particularly for people already taking multiple redox‑active compounds.
Has anyone run a short‑term PQQ trial and logged bloodwork or side‑effects? What dose did you use, and did you notice any changes in markers like ALT or resting HRV?
Community discussion - research and educational context only. Not medical advice.