Does daily 250 µg sermorelin before bed shift my GH pulse and body composition?

Question

I have been using sermorelin for about three months now, 250 µg injected subcutaneously each night about thirty minutes before sleep. Basically I wanted to see if keeping the natural GH pulsatility would improve my recovery after strength sessions and maybe reduce a bit of mid‑section fat that has been stubborn. I notice my sleep feels deeper, especially the first REM cycle, and on training days I seem to have less soreness after heavy squats. Body composition on the scale hasn’t changed dramatically, but a quick skinfold check shows a couple of millimetres less on the abdomen and a slight increase in arm circumference. I also had occasional mild flushing at the injection site, which resolved after a few minutes. I’m curious if anyone has measured actual GH peaks with this timing or if a slightly higher dose up to 300 µg is recommended for better pulse amplitude without breaking the natural feedback. Any thoughts or personal data would be helpful.

amber464 · Accepted Answer

I’ve been on 200‑250 µg sermorelin for about 10 weeks too, always right before lights‑out. My own numbers are pretty rough – I log HRV, morning weight and a weekly skinfold combo. I saw a modest dip in waist skinfold ≈1‑1.5 mm after 8 weeks and my biceps stayed the same, but my overall weight stayed flat. Sleep metrics stage‑2 % and REM latency improved a touch on my Oura, and I felt less “tight” after leg days, similar to your soreness note. I never measured GH spikes directly, but a friend who ran a small blood‑draw protocol reported a clear nocturnal pulse when the peptide was taken ≤45 min before bed, and the amplitude didn’t look bigger at 300 µg versus 250 µg – just a bit more variability. In my experience bumping the dose gave no extra benefit and slightly more injection‑site redness. Might be worth keeping the 250 µg and focusing on timing consistency rather than upping the dose.

trevor_recovery · Answer

Sounds like we’re seeing very similar trends – a slight waist drop, steadier weight and that “less tight” feeling after legs. I’ve also not measured GH spikes, but the Oura data line up with a smoother sleep architecture. Do you notice any change in morning hunger or appetite?

greg208 · Answer

Sounds spot on, amber. I’ve also been tracking skinfolds and the drop’s been tiny but consistent, and the leg‑day tightness feels less. The Oura data line up too – a few percent more stage‑2 and a quicker REM onset. If anyone’s got a cheap at‑home GH test I’ll gladly try it.

Does daily 250 µg sermorelin before bed shift my GH pulse and body composition?

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Does daily 250 µg sermorelin before bed shift my GH pulse and body composition?