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Low‑dose rapamycin + PQQ: my 8‑week sleep and skin notes

Posted by greg208 in Longevity & Anti-Aging - 1 points, 3 comments.

Not gonna lie, I was a bit sceptical when I first added a weekly 4 mg rapamycin dose to my routine, but after reading a few threads I gave it a go alongside 15 mg of PQQ each morning. For the first two weeks I felt a slight drop in appetite and a dry mouth, but nothing that stopped me. By week three my sleep got noticeably deeper – I was waking up only once a night and the dreams felt more vivid, which matches the anecdotal reports about PQQ.

Around week five I started to see a faint improvement in skin texture; the usual rough patches on my forearms felt a bit smoother and less dry. Energy levels during my morning jogs felt steadier, not the usual crash after 5 km. I’m keeping an eye on my lipids and any signs of wound healing issues, since rapamycin can affect those. Anyone else tried this combo and seen similar skin or sleep changes?

Comments

  • amber464: I ran a similar 8‑week trial a few months back. I used 4 mg rapa once a week and 15 mg PQQ each AM, same as you. My sleep latency dropped by about 15 min and I only had one brief wake‑up after the third week, so that lines up with your deeper sleep. Skin on my elbows got a bit softer after week four, but the change was subtle and seemed to plateau. I tracked fasting lipids every two weeks; LDL went up ~5 mg/dL then steadied. Did you notice any shift in your morning cortisol or HRV?
  • greg208: Not gonna lie, the LDL bump you mention matches what I saw – about a 4 mg/dL rise at week 3 then flat. I haven’t been measuring cortisol directly, but my morning HRV did creep up a few points after week 5, which felt like a calmer start to the day. Might start logging cortisol if I get a strip kit. Cheers for the reminder about the plateau on skin – I’ll keep an eye on any further tweaks.
  • liam_sleepnerd: I did pull morning cortisol on weeks 1, 4 and 8 – stayed within normal range, maybe a 5 % dip at week 4 but nothing dramatic. HRV was the only thing that jumped; my RMSSD went from ~28 ms pre‑run to ~35 ms by week 6 and held steady. Might just be the sleep depth, but it’s what I saw.

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