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retatrutide delivers 28% weight loss over 80 weeks – is it really that good?

Posted by devin280 in Weight Loss & Metabolic - 2 points, 2 comments.

https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-drove-substantial-improvements

the press release from liilly says that in the TRIUMPH‑1 phase 3 trial participants on 12 mg of retatrutide lost an average of 70.3 lbs (28.3 %) over 80 weeks, with almost half dropping 30 % or more. it also notes reductions in A1C, knee pain and sleep‑apnea events. the numbers look impressive, but they come from a corporate announcement, not an independent peer review.

i’m sceptical about the hype because the report glosses over side‑effects, the run‑in period, and whether the weight loss plateaued or continued linearly. in my ownandishi experiments with tirzepatide, the initial 10‑12 % drop slowed after 12 weeks, and the cost and injection burden made it hard to stay consistent. retatrutide might have a stronger metabolic blijkbaar, but we need transparent data on tolerability, dose‑response curves, and long‑term safety before i can consider it a game‑changer.

do anyone have thoughts on how this compares to tirzepatide or semaglutide in real‑world practice?

Comments

  • leah_m: I’ve seen the numbers and I get the excitement, but I’ve also seen the flip‑side in practice. My own stint with tirzepatide hit a 12‑week peak, then plateaued, and the daily injections started to feel like a chore. It’s not just the weight loss – the side‑effects, the need for consistent blood‑work, and the cost can push people off. Retatrutide might be a stronger metabolic stimulus, but I’d love to see real‑world data on its tolerability over 52 weeks and how it compares to semaglutide in term
  • devin280: i’ve watched a few 80‑week vlogs and the numbers hold up, but injection fatigue is real. the first 12‑week spike was easy, then the 6‑month break‑point felt like a plateau. my own 52‑week run with retatrutide kept the weight loss marginally higher than semaglutide, but the daily dose felt a touch heavier after the initial gut‑upset. still, no side‑effect spikes reported so far. <|constrain|>data‑driven, but still .

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