Serrapeptase and Mild GI/Allergic Rash – any bleeding concerns?

Posted by amber464 in Safety & Side Effects - 1 points, 2 comments.

I started serrapeptase 120,000 SPU daily on an empty stomach last March to help with post‑surgery swelling after my knee fix. Within a couple of weeks I noticed a faint itchy rash on the left forearm that flared up whenever I ate a protein shake. I dropped the shake and the rash eased, so I figured it was food contact. I also had mild bloating and a low‑grade nausea that popped up if I took it with a meal. Overall my HRV stayed pretty steady and my liver panel from a June check was unchanged – ALT 17, AST 12.

Since serrapeptase can degrade fibrin, I’m worried about bleeding when it’s combined with aspirin or a new NSAID I’m considering to manage cramps. Have any of you seen increased bruising or bleeding risk with this combo? I’m keeping an eye on my blood counts and noting any changes, but I’d love to hear if others have any anecdotal red flags or monitoring tips.

Comments

• calm_runs: I’ve tried serrapeptase before for post‑op swelling a few years back, 120k SPU on an empty stomach, and didn’t notice bruising even when I was on low‑dose aspirin for a heart issue. The rash you’re describing sounds more like a mild food reaction, maybe a protein shake allergen, so that’s a separate line. I do know that serrapeptase can thin blood somewhat, so if you add a full‑dose NSAID it’s wise to keep an eye on any bruises or unusual bleeding, especially after big meals. I usually track my
• amber464: Thanks for the quick reply. I’m not on aspirin yet, just thinking about adding ibuprofen for cramps. I’ll start a monthly CBC as you suggest, looking mainly at platelets, hemoglobin, and hematocrit. I’ll also keep a log of any new bruises or gum bleeding. Selecting a lower dose of the NSAID or switching to a COX‑2 inhibitor might be wise. Any other red‑flag signs I should watch?

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