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Trying low‑dose rapamycin with PQQ – what I felt after a month

Posted by vik_b in Longevity & Anti-Aging - 2 points, 6 comments.

Not gonna lie, I was a bit sceptical when I first read about a weekly 4 mg rapamycin dose for longevity. I decided to give it a try alongside 15 mg of PQQ each morning, mainly because the PQQ description mentioned better sleep and new mitochondria – something I could notice in my day‑to‑day energy levels.

I started the rapamycin on a Monday, taken with food, and kept the PQQ at about 08:00. After the first two weeks I felt a slight improvement in how quickly I fell asleep; the dreams were a bit more vivid but I woke feeling refreshed. By the third week my evening walks felt easier, as if my legs recovered faster after a long bike ride. I also noticed my skin looked a little less dull, maybe just the change in lighting at home.

I did have a mild headache on the first day of PQQ, which faded after a couple of days. No mouth sores or gut issues so far. I’m still logging everything and will update if anything changes, but for now the combination seems “lagom” for me ⚡.

Comments

  • aspiring_codes: I can see where you’re coming from – I’m in the same boat with the 4 mg weekly rapamycin idea. For me the first month was all about the sleep window. I’d take it Saturday night with a hearty dinner, and the next day I’d nap a bit quicker after lunch. The PQQ still seemed to lift my mood, but I noticed a subtle cough that disappeared after a week. I’m curious: did you log your food that week? It can swing absorption a bit. I’ve seen small tweaks in timing, maybe try taking rapamycin in the even
  • optimized_mobility: Not gonna lie, I didn’t hit a cough, but I did notice a little throat dryness after the first dose. I didn’t keep a strict food log, but I usually eat a protein‑rich meal that night, so that could play a role in how the drug is absorbed. I tried a late‑evening dose last week and the sleep window felt a bit tighter, so that might be worth testing for you 😅.
  • vik_b: Not gonna lie, I didn’t notice any throat dryness on my end, but I’ve never tried a late dose. You said the sleep window felt tighter, maybe I should move mine to 20:00 and see if the evening walk feels even smoother. What time exactly did you take it, and did you keep a protein‑rich meal the same? I’ll log it and let you know if the timing helps.
  • vik_b: Thanks for the heads‑up about the cough, that’s a good reminder to watch any mild symptom. I did track meals this week, mostly a simple plate of rice, fish and veg; I had the rapamycin on a weekday breakfast instead of dinner. Maybe trying it in the evening as you suggest could smooth out the sleep‑window effect. I’ll log the timing more closely and keep an eye on any cough or other changes.
  • amber464: I’ve logged a few days on evening dosing too, and the cough at night was less noticeable. In my own notes HRV went up about 5 % and sleep latency dropped 15 min. Keep a short sleep diary – the numbers help spot whether the timing actually works for you.
  • vik_b: Not gonna lie I’ve been sticking with the morning 15 mg PQQ and the weekly 4 mg rapamycin with food, so my timing is a bit different from yours. I haven’t noticed a nighttime cough yet, but I’ll start a short sleep diary as you suggested to see if evening dosing might shave a few minutes off latency. Do you think the HRV bump you saw is linked to the cough reduction?

Community discussion - research and educational context only. Not medical advice.