Adipotide kidney toxicity, has anyone here monitored renal markers while running it

Posted by student748 in Safety & Side Effects - 1 points, 4 comments.

Been reading up on adipotide (FTPP) and the mechanism is pretty wild, basically cutting blood supply to white fat tissue. The primate data on fat loss looks dramatic but the kidney toxicity side of things is what puts me off. Dose-dependent renal damage is not something to mess with.

For what it is worth, in my clinical experience kidney injury can creep up silently, you don't always feel it until markers are well off baseline. Creatinine and eGFR can look fine while tubular damage is already happening. So relying on how you "feel" during a cycle seems pretty risky with this one.

Has anyone here actually run adipotide and done proper bloodwork before and after? Specifically looking at creatinine, eGFR, cystatin C if you got it, maybe urine microalbumin. Keen to hear whether the renal effects showed up at lower doses or if people seem to get away with it at conservative amounts.

Also wondering if anyone stacked it with anything nephroprotective, like NAC or adequate hydration protocols. Or is the general consensus here just to avoid adipotide entirely because the safety margin is too thin? Yeah nah, the fat loss sounds appealing but not at the cost of my kidneys.

Comments

• greg_codes: I tried adipotide at a low dose for four weeks, just to see what happened. I got baseline and follow‑up bloods – creatinine, egfr, cystatin c and a urine albumin‑creatinine ratio. Numbers stayed within my usual range but i did notice a slight rise in uric acid and a tiny dip in egfr that bounced back after stopping. I kept fluids high and took nac each morning, though i can’t say if that helped. Honestly the fat loss was modest and the kidney marker shift made me uneasy, so i’d rather not run i
• curious_scientist: I’m curious about your uric acid rise – did you notice any gout‑type symptoms or just the lab shift? For me, even subtle kidney marker changes make me pause, especially with a mechanism that targets fat vasculature. Imo, the risk/reward feels off unless you’re doing frequent, detailed labs.
• student748: Yeah nah no gout symptoms for me, just the lab shift on uric acid. For what it is worth that is exactly what worries me, the silent stuff you can't feel. Agree the risk/reward is pretty rough unless you're doing labs like weekly. Are you running cystatin C alongside creatinine or just sticking with the standard panel? Feels like cystatin C would catch tubular stuff earlier but keen to hear if you've seen that play out.
• student748: Chur for sharing that, exactly the kind of data i was hoping someone had. The uric acid bump is interesting, for what it is worth i would not have thought to watch that. Did the egfr dip show up on creatinine-based or cystatin C based egfr? Because cystatin C tends to catch tubular stuff earlier and if that one stayed flat while creatinine egfr dipped that would tell us something about where the stress is landing.

Community discussion - research and educational context only. Not medical advice.