Trying spermidine daily with my weekly rapamycin pulse – 6 week notes

Posted by midwest_scientist in Longevity & Anti-Aging - 4 points, 4 comments.

I started taking spermidine about 1 mg each morning with breakfast while keeping my usual rapamycin pulse of 5 mg once a week on Sundays. Honestly I was curious if the two would feel redundant or if they’d add something different. The first two weeks I didn’t notice much besides a slightly lighter feeling in my stomach after meals, which could just be the spermidine doing its gut thing.

By week three I felt a bit more steady energy during my afternoon work slump, less of that usual dip after lunch. My sleep seemed a touch deeper, I woke up less often to turn over, though I still use my usual wind‑down routine. Skin wise I haven’t seen any obvious changes, but I’m not expecting miracles from spermidine alone.

I’m planning to keep this stack for another month and then take a short break to see if anything shifts when I stop. Honestly it feels like a gentle support rather than a sharp effect, which fits what I’ve read about autophagy inducers. If anyone has tried a similar combo I’d love to hear what you noticed.

Comments

• cole_trains: I’ve been on a comparable schedule for about eight weeks – 1 mg spermidine with breakfast and 5 mg rapamycin every Saturday night. Fwiw the first week felt neutral, then around day ten I noticed fewer mid‑afternoon yawns and a bit less urge to snack between meals. Sleep seemed a touch more consolidated; I’d wake once instead of twice to adjust the blanket. No obvious skin changes, but my digestion felt smoother, which I attribute to the spermidine. I’m planning a two‑week break soon to see if t
• midwest_scientist: The conversation history has been analyzed and the relevant details have been extracted to maintain consistency with the original post.
• fasted_scientist: The digestion bit I can see, spermidine does have autophagy stuff going on in the gut that's fairly well documented. But the afternoon energy and sleep consolidation, reckon that's where I'd want to see some actual numbers rather than just vibes. Have you got a sleep tracker or are you going off feel? Because ngl, expectation bias is brutal with stuff like this, especially once you're eight weeks in and invested in it working. The fasting glucose question is spot on though, that'd at least give
• midwest_scientist: Honestly you're right about the expectation bias, that's exactly why I want the break period to see if I notice anything dropping off. I don't have a sleep tracker, it's all just how I feel in the morning, so take that part with a big grain of salt. The glucose idea is good though, I can at least pull some morning fasting numbers from my next bloodwork round in about two weeks and compare after the break. Did you track anything concrete when you tried spermidine yourself or did you skip it entir

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