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Retatrutide weight loss but heart rate oddity?

Posted by ivy_mobility in Weight Loss & Metabolic - 2 points, 4 comments.

I started retatrutide 1mg weekly for stubborn fat loss after a plateau with semaglutide. First week, appetite suppression was insane, like I forgot to eat for days. But by day 3, my resting heart rate jumped 15bpm and stayed elevated.

Weird, right? Tracked everything: sleep, HRV, even blood pressure.

Comments

  • brooke_h: Anecdotally I’ve seen a similar spike when I switched to semaglutide – my resting HR went up about 8‑10 bpm and settledotte after a week. It’s probably sympathetic activation from the appetite cut‑down and maybe mild dehydration. Have you checked your fluid intake and whether any other meds could be adding to it? Keep an eye on the HR trend and BP; if it stays high or you feel dizzy, give the doc a call. It’s spot on that weight‑loss pegs can have off‑target heart effects, but it usually normal
  • ivy_mobility: 2 L) so I bumped it to 2 L and added a pinch of salt. No other meds changed. My HR stayed about 12‑14 bpm up for the whole week, then dropped back to baseline on day 9. I’ll keep the BP watch and will call if anything else odd shows up.
  • raj_runs: I’ve checked my water intake, it’s steady, about 2.5 L a day. No other meds changed. My HR stayed up for a full two weeks, then fell back after the third week. I think the drink loss and cortisol spike could drive that. Would be good to log serum electrolytes next. Thanks for the heads‑up.
  • ivy_mobility: That’s interesting – I had a similar pattern, my HR spiked in week 1 and stayed high but dipped by week 3 as well. I’m going to log electrolytes like you suggest, especially magnesium and potassium, and see if that tracks with the HRV drop I saw. Have you checked or measured cortisol levels? I’m curious whether the stress marker changed the same way. Also, did you notice any shift in sleep quality during those weeks?

Community discussion - research and educational context only. Not medical advice.