Chonluten lung bioregulator, anyone actually tried it for respiratory support

Posted by student748 in Research & News - 3 points, 3 comments.

Been reading up on chonluten (https://researchsafe.org/peptides/chonluten) after seeing it pop up in a few longevity circles. It's a khavinson tripeptide, glu-asp-gly, supposedly targets bronchopulmonary tissue and helps with airway lining integrity and mucosal immune function. The proposed mechanism is regulating gene expression in respiratory epithelium which sounds pretty interesting on paper.

For what it is worth i got curious because with the kind of mileage i run, anything that supports lung function or respiratory resilience catches my eye. Winter training down here can be brutal on the airways with cold dry mornings.

But here's my issue, there's basically no western clinical data i can find. The khavinson bioregulator stuff has been around for ages in russian literature but i struggle to assess how rigorous those studies actually are. The claims around antioxidant defense in lung tissue and local immune support sound promising but also feel like they could be heaps overhyped given the lack of data.

Has anyone here actually run chonluten and noticed anything concrete with breathing or respiratory stuff? Or is this one of those things that sounds sweet as in theory but does nothing in practice? Keen to hear any real experiences before i go down another rabbit hole.

Comments

• fasted_scientist: I've looked into the Khavinson peptide stuff before and honestly the Russian literature is hard to evaluate. A lot of it is in journals that don't get indexed well and the translation quality is rough, so you can't tell if the methodology is sound or if it's just underpowered observational stuff. Chonluten specifically I've never seen anyone on here report concrete results from, which tells you something on its own. For cold air exercise-induced airway irritation, there's actually decent data o
• labrat_vik: Yeah the lack of anyone actually reporting back on Chonluten is kind of the whole story with the Khavinson peptides, you see the same thing with Livagen and Pinealon where people get curious and then just go quiet. The Russian literature issue is real too, I've tried reading some of those papers and half the time you can't even tell what the control group was. The pre-warming air thing is underrated honestly, a simple neck gaiter over your mouth in cold weather does more for airway comfort than
• student748: Chur for that, the neck gaiter thing is a good call actually, i've been using a buff but only pulling it up when it's properly freezing, might just wear it every cold morning. For what it is worth the control group thing in those russian papers is exactly what bugs me too, like you read the abstract and it sounds promising but then you can't even tell if they had a real comparator or just baseline vs post. The livagen and pinealon going quiet pattern is a bit of a red flag eh, makes you wonder i

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