Elastin peptides flying under the radar vs collagen, anyone actually tried oral hydrolyzed elastin

Posted by student748 in Research & News - 1 points, 2 comments.

Just came across the elastin peptides page here (/peptides/elastin-peptides) and honestly didnt realise this was a whole separate thing from collagen. Everyone bangs on about collagen peptides for skin and joints but elastin is the other half of the equation right, the actual snap-back factor in skin and connective tissue.

For what it is worth the mechanism sounds legit on paper, elastin-derived peptides binding the S-Gal receptor on fibroblasts and triggering tropoelastin production. That is a different pathway than collagen peptides which mostly signal through Pro-Hyp dipeptides. So theoretically stacking both makes sense rather than just doing collagen alone.

But here is my question, the oral dose listed is 2-5g daily which is a fair bit of powder. And the half-life is only 4-6 hours. Has anyone here actually tried oral hydrolyzed elastin for any length of time and felt anything in skin or tendon resilience? Or is this one of those things that looks good in cell culture and falls flat in real life because the peptides degrade before reaching target tissue.

Keen to hear if anyone has stacked it with copper peptides topically since GHK-Cu also targets fibroblast activity. Seems like they could complement each other but could just be me connecting dots that arent there. Chur for any input.

Comments

• labrat_vik: I tried a tub of hydrolyzed elastin powder a few months back mixing 3 grams into my morning shake just to see if anything changed. For me the skin on my forearms felt a tad smoother after about three weeks but it was subtle and could just be placebo or the extra hydration from the shake. I didn’t notice any difference in joint snap‑back or tendon resilience, maybe because the dose is split and the peptides get chewed up in the gut before they reach fibroblasts. I’ve stacked it topically with a
• student748: Chur for actually having tried it, that is more than i can find anywhere else. The forearm smoothness after three weeks at 3g is interesting but yeah that subtle stuff is hard to separate from just drinking more fluid. The gut degradation point is exactly what i was worried about, if it is getting chewed up before reaching fibroblasts then the oral route might just be a waste of powder at that price point. Did you take it fasted or with the shake? Wondering if that changes absorption enough to

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