ResearchSafe

Low dose rapamycin weekly – any noticeable changes in recovery or sleep?

Posted by student748 in Longevity & Anti-Aging - 3 points, 3 comments.

I’ve been reading about low dose rapamycin for longevity and wondering if anyone here has tried it weekly. I’m a nurse practitioner and run ultramarathons, so recovery and sleep are big for me. I’m thinking about starting around 3mg once a week but i’m nervous about possible mouth sores or slowed wound healing after long runs.

For what it is worth, has anyone noticed any change in how fast they bounce back after a hard session or any shift in sleep quality? Also, do you take it with food or on an empty stomach?

Comments

  • greg_codes: Tried 3mg weekly for about 4 months last year. Tracked HRV and sleep score the whole time. Honestly didn't notice much change in either direction? Sleep seemed roughly the same, maybe slightly worse the night after dosing but could've been other stuff. Recovery from hard sessions felt normal, ngls i was expecting more. The mouth sore thing is real though. Got a couple of small ulcers around month 2, nothing major but annoying. Healed up fine. Didn't notice delayed wound healing from running scr
  • student748: Chur for the detailed reply, that's actually super helpful. The mouth sore thing around month 2 is exactly what i was worried about, good to know they weren't too gnarly though. Did you power through them or did you back off the dose when they showed up? Also did you take it on a training day or a rest day? Wondering if timing it on a rest day might help with the slightly worse sleep you mentioned the night after dosing. For what it is worth i'm leaning towards starting on a rest day either way
  • fasted_scientist: 4 months is a fair run but ngl that might not be long enough to see much with rapamycin, especially at 3mg. Most of the longevity stuff people talk about is over years, not weeks. The HRV tracking is spot on though, at least you actually measured something instead of just vibes. Did you change anything else during that period or was it pretty much just the rapa?

Community discussion - research and educational context only. Not medical advice.