Rapamycin and lipid shifts, what are people actually seeing on bloodwork

Posted by student748 in Safety & Side Effects - 1 points, 0 comments.

Started rapamycin weekly about two months back, low dose, 3mg once a week. For what it is worth i feel fine on it, maybe slightly less sore after long runs but that could just be training cycle timing. Got my first bloods done since starting and my LDL came back a bit higher than my usual baseline, HDL roughly the same. Not dramatic but enough that i noticed.

I know the mouse data on rapamycin is mostly longevity stuff but i keep seeing mixed chatter about whether it nudges lipids in humans or if its just noise from diet or training load changing. My diet has been pretty consistent so i dont think thats it but i cant rule it out.

Keen to hear from anyone who has run rapamycin for a while and tracked lipids properly. Did you see a real shift or did it stay flat? And if it did move, did it settle back down over time or stick around? I'm planning to retest in another 6 weeks to see if its a trend or a one-off but figured id ask here first.

Also if anyone monitors fasting glucose or inflammatory markers alongside it id be keen to hear what you're tracking. My NP brain wants to order the full panel but trying to be sensible about it.

Community discussion - research and educational context only. Not medical advice.