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Trying a low‑dose Superman + PE‑22‑28 combo for mood and recovery – need feedback

Posted by marcus617 in Protocols & Stacks - 12 points, 6 comments.

Hey folks, I’ve been running the classic Superman stack (CJC‑1295 100 µg + Ipamorelin 200 µg nightly plus 25 mg MK‑677 daily) for about six weeks now. I’m 49, train 4‑5 times a week, and have noticed marginal improvements in sleep quality and a bit less post‑gym soreness, but my mood has been a bit flat lately. After reading about PE‑22‑28’s TREK‑1 blockade and its rapid antidepressant signals in animal work, I decided to give it a cautious trial.

I reconstituted 1 mg in 1 ml bacteriostatic water, then took 20 µg subcutaneously every morning for two weeks, keeping the Superman doses unchanged. For me the morning PE‑22‑28 seemed to lift the mental fog a little and I felt a bit more motivated for the first training session of the day, though I can’t rule out placebo. No noticeable side effects yet, but I did get a mild light‑headed feeling after the first dose. I’m planning to continue the 20 µg for a total of four weeks and would love any thoughts on dosing, timing, or whether anyone has paired these two stacks before.

Comments

  • brandon245: Not gonna lie, I tried a similar low‑dose PE‑22‑28 add‑on to my CJC/Ipa/MK‑677 routine a couple months back. I did 15 µg subq each morning for three weeks while keeping the nightly Superman stack unchanged. I noticed a slight bump in morning alertness and felt a tad less dragging during my first workout, but it was hard to tell if it was real or just expectation. No side effects beyond a brief dizzy feeling after the very first shot. If you keep logging how you feel each day and maybe track a s
  • jason582: To be fair, I’ve tried a 20 µg morning shot Alain with the same Superman stack. I felt a subtle lift in alertness for the first hour, but then the rest of the day was inaudible change. It was hard to separate placebo from real effect. Logging a quick mood score daily helped me see the pattern. What about timing with training?
  • zoe_rows: Thanks for the heads‑up, Brando. To be fair, I’ve seen a mild lift in the first half of the day after a morning pen. I’ve kept a simple mood log; the numbers jump a little after the first week but level out. Did you notice any change in sleep or soreness during that period?
  • marcus617: I did notice a small shift in sleep – my sleep log shows about 30‑minute more deep‑sleep after the first couple of doses, and the light‑headed feeling vanished by the third dose. Soreness dropped a bit too – my post‑workout DOMS score went from 7–8 down to about 6 on the 0‑10 scale. Still, I reckon MK‑677 is doing most of the work, but the PE‑22‑28 seems to give a quick lift in the morning.
  • marcus617: Good to hear you’ve had that subtle lift too. I’ve only been on it for two weeks but I notice the boost is strongest right before the first set, then it fades before the rest of the session. I’ve been shooting it 30 minutes before training, so it lines up with the adrenaline spike. Do you dose right before or after your workout? Maybe tweak the timing and see if the post‑lift sticks a bit longer.
  • marcus617: Thanks for the heads‑up – I did get that light‑headed feeling after the first shot too and it passed quick. I’ll start a simple mood score log as you suggest to see if the lift lasts beyond the novelty. EFI: after the first three weeks of 20 µg, do you think bumping to 25 µg would keep that morning alertness without new side effects?

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