NR at higher doses, anyone get actual nausea or flushing from it
Posted by student748 in Safety & Side Effects - 1 points, 5 comments.
Started taking NR a few weeks back, been working up from 250mg to about 600mg daily. For what it is worth the lower dose was fine, sweet as, no issues at all. But once i pushed past 500mg i started getting this weird mild nausea maybe 20 minutes after taking it, not like gagging or anything just this unsettled feeling in my stomach that hangs around for an hour or so.
No flushing that ive noticed, just the GI thing. I take it in the morning with breakfast so its not on an empty stomach. Could just be me being sensitive to B3 forms, i dunno. Read that GI upset at higher doses is a known thing but nobody really talks about what "higher doses" means in practice.
Keen to hear if anyone here has run 500mg+ and had similar stuff happen, or if you found a dose where it settled. Does splitting it morning and evening help? Seems like it might spread it out a bit. Just my own experience so far, not assuming its universal.
Comments
- scott_l: I ran NR up to around 500mg for a stretch and had basically the same thing, just this low grade queasy feeling that wasnt bad enough to stop taking it but definitely annoying. For me splitting it into two doses, one morning one evening, seemed to take the edge off compared to taking it all at once. Could just be that the peak concentration in your gut is lower at any given moment, or could be placebo, hard to say. I never pushed past 500 though so I cant speak to what happens at 600+. Have you
- student748: Cheers for that, good to hear its not just me getting the queasy thing. The splitting idea makes sense, im gonna try 300mg morning and 300mg evening and see if that settles it. For what it is worth i did drop back to 400 for a couple days last week and the nausea pretty much went away, so theres def a threshold somewhere around 500 for me. Did you notice any actual benefit from the NR at 500 that made it worth pushing through the queasiness, or was it pretty subtle?
- data_labrat: Splitting the dose is solid advice fwiw, i had the same kind of queasy thing around 550mg and going to twice a day cleaned it up for me pretty quick. Could be the peak gut concentration thing like you said, or just my stomach being dramatic about it lol. Backing down to 400 for a few days is a smart way to find your threshold before committing to 600 🔬
- student748: Chur thats heaps helpful, good to hear someone else hit the same wall around the same dose. For what it is worth ill try the split dosing first since thats the least disruptive, but if it still niggles ill drop back to 400 like you said and creep up slower. Did you split yours roughly 50/50 morning and evening or was it more like most of it in the morning?
- student748: Chur thats good to hear someone else got the same thing at basically the same dose. For what it is worth ill try the split tomorrow, 300 morning 300 evening, and see if that settles it. Did you keep the split at 550 or did you push back up to 600 after your stomach got used to it? Keen to know if the tolerance builds or if its just something you gotta manage ongoing.
Community discussion - research and educational context only. Not medical advice.