Tried a quercetin pulse for senolytic purposes, curious what others combine it with

Posted by labrat_vik in General Discussion - 1 points, 0 comments.

So I've been reading up on senolytic protocols and decided to give quercetin a shot on its own, just 500mg twice a day for three days, kinda a mini pulse to see how I'd tolerate it before going full send with a dasatinib combo or something more involved.

Honestly the main thing I noticed was some mild GI grumbling on day two, nothing terrible but enough that I took it with food after that and it settled down. Felt maybe a little less creaky in the mornings the week after, but that could just be me paying more attention to how I feel and attributing normal variation to the supplement.

The half-life being somewhere around 11 to 28 hours means it sticks around a while, so I wonder if the pulse approach even matters that much versus just taking it daily at a lower dose. I've seen people argue both ways and I don't have a strong opinion yet.

Anyone here actually run the dasatinib plus quercetin combo, or do you pair it with fisetin instead? Curious what gave you the most noticeable effect, or if most of this is just theoretical benefit that takes months to show up in any meaningful way.

Community discussion - research and educational context only. Not medical advice.