ResearchSafe

Noticed mild scalp irritation after starting RU-58841, anyone else?

Posted by amber464 in Safety & Side Effects - 3 points, 4 comments.

I started using RU-58841 about two weeks ago, mixing 50 mg in 1 mL of propylene glycol and applying it to my scalp each morning. I’ve been tracking any changes in a simple notebook, noting redness, itchiness, and how the skin feels. Around day three I felt a light tingling that turned into a mild rash along the hairline where I applied the most.

It wasn’t painful, just uncomfortable and a bit flaky after washing. I paused the application for 24 hours, then resumed with half the dose and spread it more thinly. The irritation faded after a couple of days and hasn’t returned since.

I’m wondering if others have seen similar scalp sensitivity when they first start, or if it’s just a reaction to the vehicle I’m using. I plan to keep a log of application site reactions and maybe try a different solvent next cycle to see if that helps.

Comments

  • raj_j: Honestly, I’ve seen that little “first‑time burn” with a few topicals. When I started a new peptide cream on my scalp, the spot got a bit red and flaky after a couple of applications. Propylene glycol can be a weak irritant, especially if you’re putting it straight on. I tend to work in a thinner mix, like 20 mg in 2 mL, or add a bit of witch hazel or aloe to soothe. A quick patch test on a tiny patch for a day or two can flag any sensitivity before you go full‑on. How long did that rash stay o
  • amber464: The rash cleared up after about 48 hours once I cut the dose in half and spread it thinner. I didn’t see any noticeable change in hair growth yet – it’s only day 10, so I’m still in the early window. I’ll try a patch test with a 20 mg/2 mL mix and maybe add a splash of aloe like you suggested, see if that smooths out the initial burn. Thanks for the tip!
  • aspiring_codes: I had a similar flare when I first used RU‑58841 straight in propylene glycol. The rash cleared in about 36 hours after cutting the dose. I didn’t notice any change in density yet, but I’m still watching. Did you see any new shedding or thicker growth since? ❓
  • amber464: I saw the same 36‑hour clearing after cutting the dose. I haven’t noticed any shedding or thicker growth yet, my follicle count is still the same. I’ll log it more closely and try a different solvent next cycle. Have you seen any density changes on your side, and what cut did you use?

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