BPC‑157 oral protocol for stubborn shoulder tendonitis – what timing works?

Posted by aspiring_trailrun in Healing & Recovery - 8 points, 6 comments.

I’ve been battling a nagging supraspinatus tendonitis for the last three months. Physiotherapy gives me good range, but the pain flares after every heavy set and I’m keen to speed up the repair. A few weeks ago I started an oral BPC‑157 arginate regimen (500 µg once in the morning, 500 µg post‑workout) after reading about its gut‑linked systemic effects. For me the first couple of days I felt a slight nausea, but it settled after a night of a heavier meal.

Around the workout I noticed the usual post‑session soreness was milder, and after two weeks the night‑time ache had dropped from a 7/10 to about a 3/10. I’m still doing rotator‑cuff strengthening and eccentric raises, but I’m curious if anyone has tried a similar split‑dose timing or perhaps a single daily dose on rest days. Also, does anybody cycle off after a month or keep it ongoing? Cheers 🌱.

Comments

• megan_g: i've been on a similar road with my shoulder, so to be fair i can stand by your split‑dose plan. i started 500 µg in the morning and another 500 µg right after my lifting session – the nausea faded after a good chunk of rice and banana, so food does help. i noticed less post‑workout soreness after about a week, but i also tried a single 1 mg dose on rest days, and it kept the nighttime ache down to a 4/10. personally i cycle off after about 6 weeks, giving my body a break, thenulegen with 250 µ
• robin616: I’ve tried same split too – the rice‑banana trick really calms the stomach. After a month my night pain dropped to about 3/10, and the extra 1 mg on rest days seemed to keep it steady. I also tapered to 250 µg after six weeks, no flare so far. How long do you stay on the lower maintenance dose? 😎
• ethan405: I haven’t tried the 1 mg on rest‑days yet, but I’ve stuck to the 500 µg split for a month now. The night‑time ache dipped to about 4‑5/10, and the post‑workout soreness feels less intense. How about the 250 µg maintenance – do you notice any lag before the pain eases again? 🤔 fwiw.
• aspiring_trailrun: That makes sense, Ethan – I did a quick 250 µg maintenance run for a week after the first month and the night‑time ache crept back to a 5‑6/10 before I bumped back to 500 µg split. It seemed the lower dose just didn’t sustain the anti‑inflammatory effect for me. I’ll stick with the split for now but might try a single 1 mg on rest days to see if it smooths the dip. Cheers 🌱.
• aspiring_trailrun: Thanks, robin616, for the practical tips. I’ll try the rice‑banana trick – the extra 1 mg on rest days sounds sensible. I’m planning to taper to 250 µg after six weeks too, but I’m not yet sure how long to keep that lower maintenance dose. How long did you stay on the 250 µg and did you notice any change in morning stiffness or flare‑ups?
• aspiring_trailrun: I’m glad the rice and banana trick worked for both of us – I had the same mild nausea that cleared after a bigger meal. After a month of the split‑dose I’m planning a short break exactly like you suggest, then back to 250 µg daily. How did you split the 250 after the break – still morning only, or a split dose? Also, have you noticed any changes in the night‑time score after the lower dose?

Community discussion - research and educational context only. Not medical advice.