CJC-1295 DAC – does splitting the dose blunt the prolactin bump?

Posted by fasted_scientist in GH & Growth Peptides - 5 points, 6 comments.

I’ve been running CJC-1295 DAC at 2mg twice a week for a few weeks now, mostly before bed. Ngl I’ve noticed a bit of water retention and waking up feeling a tad puffy, which makes me wonder if the prolactin spike is hitting harder than I expected. 5mg every other day, to see if it smooths out the sides while still keeping GH pulses up?

I’m curious if the longer half-life means the total weekly amount matters more than the peak concentration, or if the peaks themselves drive the prolactin rise. I’m not looking for a magic fix, just wondering if anyone’s played with the schedule and felt a difference in bloat or sleep quality. Any real‑world tweaks you’ve tried would be helpful.

Comments

• tracker_jade: Anecdotally I felt the same puffiness on CJC-1295 DAC and it took me a bit to connect it to water retention rather than just poor sleep. But your math seems off there, 2mg twice a week is 4mg total, and 5mg every other day would be like 17.5mg a week. That's way more, not a split. Did you mean 0.5mg every other day or something smaller? For me the bloat seemed tied more to total weekly load than peak timing, but I never ran it long enough to really compare schedules side by side. Have you check
• restless_nof1: You’re right, my math was off – 5mg EOD jumps the weekly dose a lot. I’ve only relied on how I feel (a bit puffy, heavier limbs) and haven’t checked prolactin labs yet. Have you tried a lower split, like 1mg twice weekly, and noticed less bloat?
• sarah_codes: For what it is worth I noticed that math thing too and was gonna say something but you beat me to it. 5mg every other day is a huge jump from 4mg a week. I'm new to this stuff but even I raised an eyebrow at that. 5mg or 1mg every other day? Would still be more than 4mg weekly at 1mg but way closer. I haven't run DAC myself yet so I can't speak to the bloat... Just reading and trying to learn from you all before I mess with it.
• fasted_scientist: Cheers for catching that, you're spot on, I proper mangled the maths there. 5mg weekly instead of my current 4mg. 5mg a week and that's just daft. Ngl I typed it late and didn't double-check. Has anyone reading actually tried lowering the weekly total rather than just splitting it? Still not sure if the prolactin issue is peak-driven or cumulative.
• fasted_scientist: Cheers for catching that, you're spot on, 5mg EOD would be way more per week than what I'm doing now. Haven't tried 1mg twice weekly yet but honestly that might be the sensible next step before chasing labs. The heavier limbs thing you mentioned is exactly what I get, like waking up feeling vaguely swollen. Might drop to 1mg twice a week for a fortnight and see if the puffiness calms down. Have you felt any difference in sleep quality with the bloat, or is it mostly the physical heaviness for y
• fasted_scientist: Yeah you're spot on, my numbers were all over the place there. I meant something like 1mg every other day, not 5mg. That would've been a lovely surprise on the bloat front. Haven't checked prolactin on bloodwork yet, just going by the puffiness and how I feel in the mornings. Reckon I should probably get it done though rather than guessing. You said the bloat seemed tied to total weekly load, did lowering the overall amount actually sort it out for you or did it just take the edge off?

Community discussion - research and educational context only. Not medical advice.