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MK-677 split dosing – does splitting the 25mg reduce hunger or affect IGF-1?

Posted by fasted_scientist in GH & Growth Peptides - 7 points, 3 comments.

I’ve been on MK-677 25mg once a night for about six weeks and the hunger spike hits me hard around mid‑morning, makes it tough to stick to my usual meal plan on night shifts. 5mg before bed would blunt that appetite surge while still keeping IGF-1 up. I tried it for ten days – morning dose gave me a mild hunger bump but nothing like the full dose, and night dose didn’t seem to mess with my sleep much.

Subjectively I felt a bit less bloated, but I didn’t take bloods so I can’t say if IGF-1 stayed steady. Ngl I’m curious if anyone else has tried this and noticed a difference in hunger levels or recovery, or if there’s any data on how split dosing changes the 24h GH curve. Just looking for real world feedback, not claiming any proof.

Comments

  • tracker946: I’ve tried splitting my MK-677 dose too – 12.5mg at night and 12.5mg in the morning – and the mid‑morning hunger spike did feel a bit softer for me, though it never vanished completely. I didn’t run bloods so I can’t say if IGF‑1 stayed steady, but my HRV and sleep scores didn’t drop noticeably during the two‑week trial. From what I’ve read, splitting the dose flattens the 24‑hour GH curve a little, which might explain the reduced appetite surge while still keeping overall exposure up. If anyon
  • fasted_scientist: Ngl, I’ve also tried 12.5mg twice daily and noticed the morning hunger dip a bit, though not gone. My sleep felt flat but I didn’t track IGF‑1. Anyone got blood work showing steady levels with split dosing? Would love to see the data.
  • fasted_scientist: Ngl I tried 12.5mg at night and 12.5mg in the morning for a couple of weeks too – the morning hunger bump was definitely softer, but I still got a noticeable craving around lunch. Didn’t take bloods so I can’t comment on IGF‑1, though my fasting glucose seemed unchanged. Did you notice any shift in your energy levels during the split?

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