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Feedback on BPC-157 oral + TB-500 subQ stack for patellar tendonitis

Posted by tracker_jade in Protocols & Stacks - 6 points, 8 comments.

I’ve been dealing with a stubborn patellar tendon flare for a few months. 5mg subQ twice a week (Monday and Thursday). I’ve read the typical doses for each but I’m not sure how to time them relative to my PT sessions or if I should split the TB-500 into smaller shots.

Has anyone run a similar combo for tendon issues? Did you notice any difference in pain or stiffness after a few weeks? Also, any tips on cycle length before taking a break?

Just looking for real‑world anecdotes on safety and timing. Thanks.

Comments

  • fasted_scientist: I’ve run a similar setup – BPC‑157 oral 250mcg twice daily plus TB‑500 2.5mg subQ on Monday and Thursday. For me the ache eased a bit after about three weeks but morning stiffness didn’t shift much; could just have been taking it easier on the knee.
  • kyle711: Did you take bpc before or after pt? Did you try splitting tb500 into smaller doses? How long did you stay on before a break?
  • tracker_jade: I took the BPC‑157 oral first thing in the morning, usually about an hour before PT, and gave the TB‑500 subQ right after the session. 5 mg shots on the same days and didn’t feel a big difference. I stayed on the stack for six weeks then took a two‑week break. Did you notice any stomach upset with the oral BPC?
  • recovery797: For what it is worth, I tried the same oral BPC‑157 250mcg twice a day with TB‑500 2.5mg subQ Mon/Thu. Pain dropped around week 3, stiffness stayed similar; I noted better HRV scores after PT when I dosed 30 min before session.
  • tracker_jade: Appreciate the specifics. Interesting that you ran 2.5mg TB-500 instead of 5mg, I might drop mine down to that. The 30-min-before-PT timing is a good call, gonna try that Monday. Did you take the full 2.5mg in one shot or split it? Also how long did you run the cycle before taking a break?
  • tracker_jade: 5mg vs my 5mg. Did you land on that dose from prior cycles or just started there? Anecdotally I'm wondering if the higher dose is overkill. The morning stiffness sticking around is kinda what I'm worried about, that's the part that bugs me most too. Did you end up running it past four weeks or stop there?
  • fasted_scientist: Reckon 5mg twice a week is on the higher end for tendon stuff, ngl. 5mg twice weekly. Starting high and hoping for faster results is tempting but there's nothing really showing more equals better here (not that the human data is great to begin with). Did you feel anything different in the first two weeks vs weeks three and four? That might tell you if the dose is doing extra work or just sitting there.
  • tracker_jade: Yeah that's fair, I kinda went in hot with the dose. Anecdotally the first two weeks I felt maybe a little less stiffness in the mornings but honestly could've been the PT work itself. Weeks three and four is where the pain actually dialed back a notch during squats. So maybe the higher dose was overkill early on. 5mg twice a week would've gotten me to the same place, just slower?

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