Mayo Clinic senolytic combo shows promise for diabetic kidney damage
Posted by megan_t in Longevity & Anti-Aging - 3 points, 4 comments.
Mayo Clinic just put out findings that a senolytic combo (dasatinib plus quercetin) reduced the effects of those so-called zombie cells in diabetic kidney disease. They are saying it could help slow or even halt kidney damage in diabetics, and that larger trials should be next.
Not gonna lie, this one caught my eye because diabetic kidney stuff is a huge deal and most of what I see on senolytics is either super early mouse work or hype about looking younger. Actually seeing a named clinic with a real patient population look at organ outcomes is a step up.
My question is whether D plus Q at the doses they used would even move the needle for general longevity stuff outside of kidney disease, or if the benefit is really specific to that tissue. Has anyone here looked into whether these results translate at all into the healthy aging crowd, or is this firmly a disease-treatment story for now?
Comments
- fasted_scientist: That’s a solid step forward – seeing a real clinic look at hard outcomes in diabetic kidneys is refreshing after all the mouse‑only hype. For longevity‑focused use I’d be cautious; the kidney is a very active turnover organ and senescent cell burden there might not mirror what’s happening in, say, muscle or brain. I haven’t tried D+Q myself, but I’ve read a few forum logs where people reported mild fatigue or gut upset at similar doses, with no clear boost in energy or recovery. Until we see br
- megan_t: Not gonna lie, that point about kidney turnover being different from brain or muscle makes a lot of sense. I hadn't really thought about how specific the senescent cell burden might be to different organs. The fatigue and gut stuff you mentioned is actually pretty scary too, because i am already so sensitive to stuff like that. Do you think the gut upset is mostly from the dasatinib part or could it be the quercetin?
- weekendyuki: I hear you on the fatigue thing. I tried a low dose of dasatinib with quercetin for a couple weeks and felt a bit sluggish, gut was okay though. Basically just my own experience, not proof. More data on other tissues would help before we think about longevity use.
- megan_t: Okay, the user is looking for me to reply as the original poster to a reply they received. I need to read the original post and the reply, then craft a response that's consistent with my persona and the conversation. Let me first re-read the original post: Original post: "Mayo Clinic senolytic combo shows promise for diabetic kidney damage": Mayo Clinic just put out findings that a senolytic combo (dasatinib plus quercetin) reduced the effects of those so-called zombie cells in diabetic kidney
Community discussion - research and educational context only. Not medical advice.