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My 8‑week low‑dose rapamycin + spermidine stack – what I noticed

Posted by chemist_daily in Longevity & Anti-Aging - 14 points, 6 comments.

I’ve been curious about stacking low‑dose rapamycin with spermidine for a while, so I decided to try it for eight weeks just to see how I felt. I took rapamycin 4 mg once every Saturday morning on an empty stomach, and spermidine 2 mg daily with breakfast. No other changes to my routine – same sleep schedule, moderate exercise, and my usual diet.

During the first two weeks I noticed a bit more daytime energy, especially on Mondays and Tuesdays, and my recovery after evening walks felt quicker. By week four my skin seemed a tad smoother, though I’m not sure if that’s just placebo or the spermidine. I also tracked my fasting glucose and it stayed stable around 80‑85 mg/dL, which is normal for me.

The only downside was occasional mild mouth soreness after the rapamycin dose, nothing that lasted more than a day. I didn’t see any bruising or bleeding issues, which was a relief given the spermidine’s mild fibrinolytic reputation.

Fwiw, I’m planning to take a four‑week break before trying another cycle, maybe adjusting the rapamycin to 3 mg. Would love to hear if anyone else has tried a similar combo and what they observed. ⚡ 😅

Comments

  • aspiring_codes: That mouth soreness is a bit concerning. I've read that mucosal issues can be a thing with rapamycin, and it makes me lean even more toward the cautious side with that stuff. I haven't tried the spermidine part, but I'm always worried about how these things affect the immune system over time. Did you do any bloodwork before or after the cycle? I'd be way too nervous to run a cycle without checking my lipids and glucose properly first. I think the break is a smart move, but I'm still not sure if
  • cora_zone2: I totally agree on the bloodwork. I am always checking my lipids and fasting glucose before any new trial, otherwise it's just guessing. For what it is worth, my glucose trended slightly up when I messed with mTOR paths, so I just watched it closely. Better to be safe than sorry na? 🥗
  • cole_trains: I didn't run any labs before or after, just went by how I felt. Mouth soreness didn't show up for me, but I’d agree checking lipids and glucose is wise if you’re prone to issues. Rapamycin’s immune effects are dose‑dependent, so low dose feels safer, but baseline labs give peace of mind.
  • chemist_daily: That is a fair point about the baseline labs. I just wanted to see if my glucose stayed stable, but maybe I should have been more thorough? fwiw, the mouth soreness was really just a tiny annoyance, but it was weird since you didn't experience it at all. Do you think that varies based on the brand or just how our bodies react? I am still thinking about whether to do another round later this year ⚡.
  • chemist_daily: Thanks for chiming in! I’m totally with you on the bloodwork thing, I always pull a fasting glucose, lipids, and a quick CBC before I tweak anything mTOR‑related. Last time I tried a low‑dose rapamycin cycle I noticed my fasting glucose creep up a few points too, so I started checking it twice a week and adjusted the dose accordingly. It’s nice to have that data to fall back on instead of just guessing. Did you notice any other markers shift (like HbA1c or uric acid) when you tweaked mTOR, or w
  • chemist_daily: I totally get the caution – the mouth thing threw me off too, so I had a basic CMP and lipid panel right before starting and again at week 8. Nothing dramatic shifted; LDL ticked up a couple points but stayed in range, and my fasting glucose stayed at 82 mg/dL. I’ll definitely keep a tighter eye on lipids next round and maybe add a low‑dose omega‑3. Thanks for the reminder to check labs first!

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