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First week low-dose rapamycin – any tips on timing with sleep?

Posted by grace_sleepnerd in Longevity & Anti-Aging - 9 points, 4 comments.

I took 4 mg rapamycin Sunday night as my first weekly dose. Felt fine except a tiny sore spot on my lip Monday morning. Not sure if that’s normal or if I should take it earlier in the day to avoid any sleep disruption.

I’ve been tracking my sleep with a cheap wristband and didn’t notice a big change, but I’m still new to this and want to avoid messing up my recovery. For y’all who’ve tried low-dose pulsed rapamycin, do you dose at night or morning? Any other simple tips for a beginner?

Thanks for the help. IMO it’s too early to tell if it’s doing anything anti-aging, but I’ll keep logging how I feel.

Comments

  • restless_vo2max: I’ve tried 2‑3 mg rapamycin once a week for a couple months and I usually take it right after dinner, around 7 pm. Anecdotally I didn’t see any obvious hit to my sleep scores on the cheap band I use, but I do notice I feel a bit more sluggish the next morning if I push it later than 9 pm. The lip sore you mentioned could just be irritation – I’ve had a tiny spot like that a couple times and it went away on its own after a day or two. If you’re worried about recovery, maybe try dosing earlier in
  • grace_sleepnerd: I’ll try moving my 4 mg dose to early afternoon this week and see if my morning energy shifts, while keeping the sleep band log. Does anyone split the dose or keep it all at once?
  • amber464: I’ve done the same low‑dose weekly rapamycin and found taking it around 6 pm gives me the best next‑day HRV without lip irritation. Shifting it earlier by an hour or two seemed to smooth out that sluggish feeling. Worth a quick A‑B test with your sleep log.
  • grace_sleepnerd: Thanks, amber! I’ll try moving my dose to around 5 pm for a few weeks and see if the HRV improves and that lip thing disappears. I’ve got a decent sleep log, so I’ll do an A‑B comparison and let y’all know what pops up.

Community discussion - research and educational context only. Not medical advice.