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Anyone tried adding Kisspeptin-10 to an existing peptide stack for HPG axis support

Posted by tracker_jade in Protocols & Stacks - 0 points, 4 comments.

I run a GLOW stack and I'm considering adding Kisspeptin-10 for HPG axis support. Currently on low-dose testosterone enanthate and my natural LH/FSH are basically suppressed to nothing, which tracks.

The dosing info I'm seeing is all over the place though. Some sources cite 1-10 nmol/kg which seems clinical and way too high for what people are actually running. Others mention 100-400 mcg 1-2x daily. For a 130 lb female, what's actually realistic here?

Comments

  • tiredmira: Honestly the dosing confusion makes sense because most of the published Kisspeptin work is in male fertility protocols or acute bolus studies, not chronic female use. The continuous infusion trials used much higher amounts but given over hours in a clinical context, which is not comparable to subcutaneous shots. For reference ranges you see in forums, 100 to 300 mcg a couple times a day is the common ballpark people report trying, but that is basically all anecdotal. One thing I'd want to know
  • gina636: Yeah that makes sense, the clinical infusion doses throw off the picture completely. Prolactin is a good call honestly, I never even thought about that pathway with kisspeptin. What kind of number should I be looking for on bloodwork, like is there a range where adding it would actually make sense vs just messing things up more?
  • tracker_jade: Not gonna lie, that's a I'm not sure I have a clean answer. Anecdotally I see people start it when LH and FSH are both under like 1 or 2, but I've also seen posts where guys run it prophylactically just to keep the axis "talking" while on trt. I'd probably look at where your LH/FSH sit now, run kisspeptin for 4-6 weeks, and re-test. If LH comes up even a little that tells you something. Anyone else have a better take on this?
  • tracker_jade: Yeah prolactin was checked last bloodwork, sat at like 8 ng/mL so middle of range, nothing weird. The bolus vs infusion distinction makes sense, that probably explains why the clinical numbers look insane. Are you running Kisspeptin yourself or just helping me think through the math?

Community discussion - research and educational context only. Not medical advice.