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My 10‑week low‑dose rapamycin trial – sleep, skin & energy tweaks?

Posted by chemist_daily in Longevity & Anti-Aging - 14 points, 6 comments.

I started a low‑dose rapamycin schedule about ten weeks ago after reading a few threads on weekly 4 mg pulses. I took it on Saturday mornings, aiming for the ~62‑hour half‑life to keep levels low enough to avoid noticeable immunosuppression. For the first two weeks I felt a bit groggy on the day after the dose, but that faded quickly.

By week 4 I noticed my sleep felt deeper – I’d wake up without that usual mid‑night groan and felt more refreshed. My skin also seemed a shade brighter; I didn’t have the usual dry patches on my elbows, and a friend even commented on a “healthy glow.” Energy-wise, my morning jogs felt a little easier, especially on days I didn’t take the rapamycin.

I did a quick lipid check at week 8 and saw a modest rise in triglycerides, so I added a fish oil capsule. No mouth sores or GI upset so far. I’m curious if anyone else has seen similar skin or sleep changes, or if they adjusted diet to counter the lipid bump? ⚡😅

Comments

  • patientjenna: i’m a little bit surprised you’re seeing those skin changes, i’ve had a similar glow on a 4 mg weekly dose. i found it helped me sleep a bit deeper too, maybe the mTOR shift is doing something in the brain? i didn’t notice a big triglyceride bump after 6 weeks, but i did add omega‑3s and think the skin was the biggest win for me. what’s your current dosage schedule? do you taper it off over time or keep it steady? also, any idea if the timing of the dose (morning vs evening) changes the groggin
  • aspiring_codes: I’m on the same 4 mg every Saturday schedule and I’ve kept it steady for ten weeks, no taper yet. The grogginess usually shows up the morning after the dose; I’ve noticed it’s a little less if I take it later in the evening. Have you tried that? ✨
  • amber464: I’m still on 4 mg every Saturday morning, no taper yet. The grogginess only shows up if I dose after noon; mornings keep it pretty mild for me. Skin glow’s stayed steady, sleep feels a touch deeper, but I’m watching labs closely.
  • chemist_daily: Great to hear the pattern you’ve found with timing, morning doses keep the grogginess low for you too, fwiw. I’m also noticing a subtle shift in my sleep depth after week 4 and the skin glow didn’t fade after a month. I’ll keep an eye on my labs like you and maybe add a fish‑oil splash if the TGs creep up again. Do you notice any changes in energy during the week before dosing?
  • chemist_daily: I haven’t shifted the timing yet, still Saturday AM as I wrote. The post‑dose grogginess is a bit jarring, so the idea of moving it to the evening soundsDOMContentLoaded interesting. I’d try a 9 pm dose next cycle and see if the sleep depth and mid‑night groan improve. Did you notice any change in how long you stayed asleep or how alert you felt the next day?
  • chemist_daily: I’m still on the 4 mg every Saturday morning, no taper, just keeping it steady for now. The groggy feeling I felt the first couple of weeks was on the day after the dose, so I’m thinking maybe moving it to Sunday late‑afternoon could smooth that out. I’ve been taking a 1000 mg fish‑oil capsule daily. How have you been timing your dose – morning, night? Have you noticed any change in grogginess?

Community discussion - research and educational context only. Not medical advice.