Brazilian sisters over 100 studied for longevity clues
Posted by dominic539 in Research & News - 1 points, 6 comments.
Reuters ran a piece about scientists studying three Brazilian sisters, all centenarians, looking for what keeps them going past 100. The researchers are doing genetic and metabolic work, trying to figure out if there is something protective in their biology that regular people don't have.
For me this is the kind of longevity stuff I want to see more of, not another supplement roundup. Real people, real data, and the fact that they are Brazilian makes me proud, no? But I stay skeptical until I see the actual study. "Clues" can mean a lot of things, and centenarians are a weird group because they survived everything already, smoking, bad food, whatever. Hard to know what actually caused the longevity.
Has anyone here seen the underlying paper? Curious if they are looking at inflammation markers or something more specific like telomere stuff.
Comments
- greg208: Yeah this sort of thing is exactly why i hang around this corner of the forum. Not gonna lie im a bit bored of the usual "top 10 supplements" stuff, real human data is what i want. The survivor bias point is spot on though, if someone smoked till 90 and still made it to 101 you cant really say the smoking was fine, its just noise. Im also keen to know what theyre actually measuring, inflammation markers or proper omics stuff.
- dominic539: Totally agree with you on the survivor bias thing, that was the part that bugged me most when I read it. And yeah I would love to see proper omics, not just the usual CRP and lipid panel (like they show in every longevity article). If I find the actual paper I will come back here and drop the link, no? Maybe somebody else already saw it.
- grinder265: The survivor bias thing is honestly the biggest issue with longevity research in general. Those studies get hyped but the people who lived to 100 are already the outliers. If they are doing full omics id be way more interested than just CRP and IL-6 panels. Have you seen what a proper metabolomics setup even looks like?
- dominic539: Yeah that is the part that bother me too. People jump to conclusions because someone reach 100, but you don't see the ones who did all the "right" things and still died at 70, right? Survivor's bias is real and most people forget it. I am curious about the omics side too, full metabolomics sounds interesting but I am honest, I don't fully know how a proper setup work. What is the main difference between a standard inflammatory panel and a real metabolomics run, in practice? Cost? Number of mark
- tracker_jade: Yeah survivor bias is a real headache with centenarian studies. I’d love to see the full multi‑omics data before getting excited. If anyone finds the paper, please post the link.
- dominic539: Yeah survivor bias is exactly what gets me, right? Like these sisters made it past 100 which is amazing, but what killed their siblings or cousins that didn't make it, no? That part of the story matters too. And multi-omics sounds great in a press release but I want to see the sample size and controls first. I will try to dig up the paper this weekend and post it here if I find something.
Community discussion - research and educational context only. Not medical advice.