FGL peptide for memory, anyone running it solo before adding anything else?

Posted by retired_coldplunge in Cognitive & Nootropic - 2 points, 4 comments.

I've been digging into FGL lately, the NCAM-derived one that works on the FGFR pathway (linked the profile here: /peptides/fgl). The plasticity angle has me curious because most of the nootropic peptides I've tried so far tend to work through BDNF or the HGF/c-Met system, so this one feels like a different lane to me.

For context I've got some time on Semax and Adamax already, both intranasal, and I've played with Dihexa oral at 10mg. Dihexa was the one that actually surprised me, took a couple weeks but my recall for names and routes I'd forgotten seemed sharper, fwiw (could easily be placebo, I tracked it but that's hardly proof).

I'm thinking about running FGL on its own for 4 to 6 weeks before stacking it with anything, just so I can actually notice what's doing what. The 1 to 5 mg/kg research range seems wide though, and I've no idea where a reasonable starting point actually sits for an adult human.

Has anyone here tried it solo, and if so what dose did you land on and how long before you noticed anything? Did you keep it or end up stacking? 📰

Comments

• weekendnate: Dihexa was my favorite of the nootropic peptides I tried too, and the recall thing was real for me as well after about two weeks. The subjective clarity was noticeable. For FGL I started low and went solo for the same reason, monotherapy first so I actually know what is doing what. Mouse studies are basically all done in the 1 to 5 mg/kg range, so on paper that translates to roughly 0.1 to 0.5 mg/kg for a person if you do a simple allometric scaling, which is a lot wider than most peptide resea
• retired_coldplunge: Yeah the scaling thing confused me too, that range is huge. I went in the lower end to start, partly because I wanted to be able to tell if anything was actually happening. Curious if you noticed anything in the first week or if it took the full two like Dihexa did for you?
• rachel_ketogen: The monotherapy approach is the right call for sure. You want a clean signal before you start stacking. And yeah that mouse-to-human scaling math is ballpark at best, people metabolize these compounds so differently. I usually start at the low end of published ranges and titrate based on what I actually feel, not just what the math says should happen.
• retired_coldplunge: Thanks for that. Starting low and titrating makes sense, I just honestly don't know what "feeling" FGL even looks like, eh? With Dihexa it was subtle and took weeks, not something I'd notice day to day. Did you find FGL gave you any kind of same-day signal to work with, or is it more of a slow creep where you just sort of realize one morning that things are clicking better?

Community discussion - research and educational context only. Not medical advice.