CagriSema dual pathway appetite suppression, anyone tried it off-label yet?

Posted by weekendnate in Weight Loss & Metabolic - 1 points, 6 comments.

Curious if anyone here has actual experience running CagriSema outside of a trial. The dual amylin plus GLP-1 mechanism looks interesting on paper because the satiety signaling is hitting two different pathways in the brain, so theoretically you could get appetite control without pushing the GLP-1 dose as high.

I have been on tirz for about six months and the food noise is basically gone, but I am starting to wonder if adding an amylin analog would give me another lever when I inevitably stall. I have seen the CagriSema profile on the site and the 20 to 25 percent weight loss claim is eye catching, though I take all of that with a grain of salt since it is from the manufacturer.

For those who have tried it, how did the nausea compare to a straight GLP-1 monotherapy? Did the appetite suppression feel qualitatively different or just stronger? Also curious if anyone has run bloodwork before and after to see if the metabolic markers like fasting insulin or triglycerides moved differently than they did on tirz alone.

Comments

• elle_z: Honestly i havent tried cagrisema yet but the dual pathway thing is what caught my eye too. Tirz already killed my snacking brain but plateaus are real and im running out of levers 😅 the amylin angle feels different from just cranking up glp-1 dosing. For nausea, id guess it stacks but thats just my guess, depends how the receptor profiles overlap. Would love to see someone post bloodwork on this cause the metabolic markers are what id actually care about, not just scale weight.
• fasted_scientist: Ngl the bloodwork angle is what i keep coming back to as well, scale weight is such a noisy endpoint and anyone whos tracked fasting glucose and lipids properly knows the real story is usually in those numbers. One thing id push back on though, receptor overlap for nausea isnt really a clean sum, amylin and glp-1 hit different brainstem pathways so it might surprise people. Keen to see if anyone actually posts decent labs from a cycle.
• fasted_scientist: Bloodwork is the right thing to watch, agreed. Scale weight lies plenty even when you're losing fat (water, glycogen, the usual). And yeah nausea stacking is a real concern with cagrisema, the amylin bit seems to hit a different nausea pathway than glp-1 but receptors overlap enough that i'd be cautious about going straight to full doses. Ngl if you stall on tirz the cleaner move might be pushing tirz higher first, amylin on top feels like a leap when you havent maxed the lever you've already go
• weekendnate: Yeah, fair point on the lever thing. I have been sitting at 10mg of tirz for about eight weeks now and the scale has basically flatlined within two pounds either way for three weeks. Lib is decent, food noise still muted, I am just stuck. Before I add anything new I think I am going to bump to 12.5 and give it another four weeks and actually pull a fasting insulin and a lipid panel so I am not just staring at the scale. If I am still spinning my wheels after that, then maybe the amylin conversa
• weekendnate: On the brainstem pathways, I had been thinking of it too simply as additive when the receptors are probably doing their own thing downstream. The fasting glucose piece is exactly why I run a CGM, because my scale can swing four or five pounds in a day and tell me nothing. What lipid markers do you focus on when you are evaluating a peptide cycle? ApoB matters more than LDL for me but I am curious what others pull.
• weekendnate: Yeah, the bloodwork piece is what I am most curious about too. A1c, fasting insulin, lipid panel, the stuff that actually tells you whether the dual mechanism is doing something different than just eating less. Scale weight can lie. If I end up trying it I will probably run a panel before and at the 8 week mark and share the numbers here.

Community discussion - research and educational context only. Not medical advice.