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Tesofensine vs GLP-1 appetite suppression, what the actual difference feels like

Posted by tiredmira in Weight Loss & Metabolic - 0 points, 4 comments.

Been digging into tesofensine lately and the appetite suppression profile looks really different from what i'm used to on tirz.

GLP-1s for me basically kill food noise through this slow, full feeling. Like i just forget to eat and when i do eat i'm satisfied with way less. Very gradual.

Tesofensine from what i'm reading works more on the dopamine and reward side of hunger, so theoretically you're still hungry physically but the drive to actually go eat is gone. Different mechanism entirely.

That long half life (8 to 10 days) is kind of wild to me. That means once it's in your system it's in there. No missed dose rebound like you can get coming off a GLP-1 week.

The dry mouth and heart rate stuff gives me pause though. I'm already someone whose resting hr trends on the higher side.

For anyone who's actually tried both, did the hunger feel qualitatively different or is it all just "i don't want food" at the end of the day? Curious if the dopamine angle really shows up in practice or if it's just a slightly different path to the same place.

Comments

  • grinder265: Haven't tried tesofensine myself so take this with a grain of salt, but the mechanism diff you described lines up with what i've read. The dopamine reward angle is interesting bc if the physical hunger is still there but the motivational pull is gone, that's a weird headspace to be in long term imo. The half life thing is what would scare me most. 8-10 days means if you get sides you don't like, you're stuck with them for a WHILE. With a GLP-1 at least if it's not working or the sides suck you
  • tiredmira: Yeah that headspace comment kinda nails my hesitation too. Like, I don't love the idea of being physically hungry but mentally checked out from food long term. Sounds like it could mess with your relationship with eating. And you're so right about the half life being a double edged sword. Steady levels sound great until you get a side effect you hate and you're stuck riding it out. GLP-1 half life is annoying for rebound but at least you have an exit ramp. The cardio thing is probably my dealb
  • retired_coldplunge: Yeah the long half life is exactly why i never pulled the trigger on it. Tirz i can stop on a friday and by the next weekend i feel normal again. With something that hangs around 8 to 10 days i wouldn't feel like i had a real off switch if things went sideways. The resting hr thing also bugs me too, fwiw (i keep an eye on mine with my watch anyway).
  • tiredmira: Yeah, the half life is actually what made me curious but also what held me back. Like with tirz if i get a weird side effect i can pause and it's out in a few days. Tesofensine you're basically committed for over a week minimum once it builds up. The hr thing, are you already in the 70s+ resting or just tracking it for general trends? I sit around 68 to 72 and that's why i haven't tried yet either, even though the appetite mechanism sounds appealing compared to feeling slowly full all day 😅

Community discussion - research and educational context only. Not medical advice.