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Feedback on a recovery-first stack after knee surgery (KLOW + sermorelin?)

Posted by carla_codes in Protocols & Stacks - 4 points, 6 comments.

Had a partial meniscus repair about 6 weeks ago and i am finally cleared to start loading the leg again. Before this i was running a pretty simple GH stack at night, mostly for sleep and recovery, but tbh i want to push healing a bit harder now that i am back in the gym.

Thinking about running KLOW during the day for the local tissue repair stuff (BPC, TB-500, GHK-Cu, KPV all in one, easier than pinning four vials) and keeping sermorelin at night before bed for the GH pulse while i sleep. So basically a split: regenerative peptides in the morning around training, and the GHRH fragment at night.

Two things i am not sure about. First, does it make sense to run sermorelin every single night long term, or is on/off cycling better to keep the pituitary responsive? Second, anyone had experience layering sermorelin on top of an already healing-focused stack like KLOW, any overlap or weird interactions i should watch for? My IGF-1 was tested before surgery and was on the lower end of normal if that matters.

Comments

  • student_mel: Congrats on the clearance, that is a big milestone after a meniscectomy. Splitting regenerative peptides around training and sermorelin at night makes sense in theory, the two are doing different jobs, but I would be cautious about loading four compounds at once when you are just back to loading the leg. On sermorelin, nightly use is what most people seem to do, but cycling off for a week every 6 to 8 weeks is common enough that I would consider it rather than running it non stop. Your pituitar
  • carla_codes: Thanks for the reply. Yeah the cautious approach is fair, tbh i was already cutting KLOW down to just BPC and GHK-Cu for now and skipping TB-500 and KPV until the leg tolerates more load. You mentioned watching my IG-1, is that mostly to make sure sermorelin is actually doing something, or is it more about catching a fasting glucose creep? I have not pulled bloods since before surgery and i should probably get a baseline before i start adding things back in...
  • fasted_scientist: Honestly the cycling off sermorelin bit is fair, but the four compounds thing is more about reconstitution hassle than actual risk imo. KLOW is just convenience, the doses are tiny, and none of them carry the kind of systemic baggage where stacking them matters. Where's the downside you're actually worried about?
  • carla_codes: Ok fair point, the convenience angle was honestly the main reason i leaned toward KLOW, not because i thought the doses would interact. My worry was more about the immune side of KPV since i'm already 6 weeks post-op and i don't want to blunt anything while my body is still in active repair mode. Does KPV actually do that at the doses in KLOW or am i overthinking it...
  • grinder265: Ngl getting bloods first is the move, IGF-1 and fasting glucose are both worth a baseline. IGF-1 tells you if sermorelin is actually moving the needle, glucose creep catches if something is pushing insulin resistance without you noticing. Both useful, both cheap to add to a CBC.
  • carla_codes: That is a, i should have done baseline before i started the GH stack months ago and i did not. Not too late though. Are you running IGF-1 and fasting glucose at the same time as CBC or separate? My GP is usually happy to add stuff on if i ask but they push back a bit if i cannot give a reason beyond "biohacking"...

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