Spermidine log week 3, plus a question about stacking with rapamycin later

Posted by sanjay_j602 in Longevity & Anti-Aging - 1 points, 4 comments.

Okay so I started spermidine about three weeks back, the polyamine kind, and I genuinely did not expect to feel anything but my face looks less puffy in the mornings and my skin just looks a bit more even, could absolutely be placebo or could be the autophagy thing finally kicking in, I am not going to pretend I can tell. I am taking it once a day in the morning on an empty stomach and that seems to work fine, no GI stuff for me so far which I know can happen. The thing that got me curious enough to start was reading about it inducing autophagy and basically mimicking caloric restriction without the actual fasting, and at 30-something in Singapore with the kind of sleep and training load I put myself through, anything that helps cellular clean-up sounds worth a shot to me.

Now the question part, has anyone here tried layering spermidine with low dose pulsed rapamycin down the line? I know rapamycin also hits the autophagy pathway through a different mechanism (mTOR inhibition) and I am trying to think through whether stacking makes sense or if that is just asking for too much immunosuppression. Would love to hear what others running a longevity stack have done.

Comments

• sean_h: Honestly the skin thing took me by surprise too, started noticing my under-eyes looked less heavy after maybe 2 weeks in, no idea if it is the autophagy or just better sleep lining up by coincidence, but I will take it. On the rapamycin question, that is a whole different beast mate, you are talking about a prescription immunosuppressant that needs a doc on board and proper bloodwork, not something you just slot in next to your spermidine and hope for the best. I would be chatting to someone who
• sanjay_j602: Yeah the under-eye thing is real for me too, same kind of timeframe, probably a couple weeks in I looked in the mirror one morning and thought okay that's different, whether it is autophagy or just finally sleeping through properly I cannot say but I will take it too haha. And yeah you are right about rapa, I know it is not something you pick up and stack casually, that is literally why I asked, I was curious if anyone had actually run it under a doc and what their bloodwork looked like before g
• aspiring_grinder: Yeah the skin thing is what surprised me as well, did not even go in expecting anything there honestly. And i actually agree with you on rapamycin, that one is a hard no without a doctor involved. The question i would push back on is whether stacking them even makes mechanistic sense in the first place though, since both seem to hit autophagy pathways, you would want to know if you are just overstimulating one route while leaving others idle.
• sanjay_j602: Honestly yeah that is the exact thing that was nagging me too, like if both are pushing the same mTOR suppression pathway are you just doubling up on one lane while the lysosomal stuff sits there doing nothing. Curious if anyone with more biochem background can actually speak to whether pulsing rapa at like 5mg once a week even does anything meaningful on top of spermidine, or whether it is basically just expensive redundancy 😅

Community discussion - research and educational context only. Not medical advice.