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BPC-157 + TB-500 split dosing around 50k training block, timing questions

Posted by grinder265 in Protocols & Stacks - 7 points, 6 comments.

Bout to start a 10 week build toward a 50k in early spring and I wanna dial the recovery stack timing before I commit. Current plan is BPC-157 250mcg 2x daily (AM + post-run) and TB-500 around 2mg 2x weekly, split Mon/Thu. Ngl the TB-500 dosing math still bugs me, most sources point to a loading phase but I cant tell if thats actually backed up or just cycle lore at this point.

For the long runs I usually do them Sat, anywhere from 22 to 30 miles depending on the week. Should I push the AM BPC dose right before the run or is post-run the better window? And do I keep TB-500 on its own days or shift it around the big sessions, like load the dose the night before a 28 miler?

Curious if anyone running a similar ultra block has experimented with splitting BPC subq vs IM, or if thats another rabbit hole that doesnt matter much. Bloodwork baseline done last week, planning a mid-block pull too. Not looking for miracles, just trying to cut down on the cumulative tendon/achilles nag I always get around week 6 of a build.

Comments

  • formerjosh: Congrats on the block, 50k build is no joke. For timing, I would keep AM BPC on an empty stomach at least 20 to 30 min before the long run, then redose post-run once you cool down. Pre-load seems to help me with the tendon stuff more than waiting until after, though it could just be routine at that point. On TB-500, I would not chase a loading phase. The 2 mg twice weekly split is what most people settle on long term, and shifting it around a big session never seemed to do anything obvious for m
  • chemist_data: Yeah the loading thing always bugged me too, the data on actin binding and tissue distribution doesnt really support a separate load vs maintenance in humans, mostly rat stuff extrapolated way too far. For long runs I agree empty stomach pre-run made a difference for me with tendon achiness, post-run dose within the hour worked fine for general soreness. Subq into the abdomen was my go to, rotated sides so no irritation built up.
  • aspiring_grinder: I hear you on the pre-load helping tendons, but do you actually think that is a real pharmacokinetic effect or more that you are just warming up and moving? Bpc has a pretty short half life from what I know, so I am sceptical it is doing much systemically 20 min before a run. Would love to see anything that shows a difference pre vs post for actual tissue outcomes, because right now I think most of it is just how the run itself feels.
  • grinder265: Ngl thats a fair challenge. The half-life on BPC is like 4-6 hours from the limited human data, so hitting it 20 min pre-run probably isnt doing much systemically by the time youre hammering down at mile 18. I think youre right that the perceived benefit is mostly the warm-up and increased blood flow to the area during the actual session. Im still gonna pin pre-run for the local tissue hit though, mainly because post-run my gut is usually trash and I wonder if absorption takes a hit when GI dis
  • grinder265: Appreciate the input, the rat to human extrapolation point is exactly what was bugging me, good to hear someone else land there. Pre-run empty stomach is interesting though, I had it pinned for post-run only since I figured digestion would compete with absorption but maybe thats overthinking it. Subq abdomen rotation noted, Ive been doing it near the injury site which might be the old bro way of thinking. Gonna try moving one dose pre-run on Sat long days and see if the tendon grumbling in week
  • grinder265: Yeah the pre-run empty stomach timing tracks with what I was thinking, good to hear you noticed a difference with the tendon stuff. The no-loading consensus on TB-500 is reassuring, I think I was just second-guessing myself because the loading phase idea gets repeated everywhere but nobody cites actual sources for it. Think Ill stick with the Mon/Thu split and not overthink moving it around the Saturday sessions. Appreciate the subq confirmation, seems like IM is the rabbit hole I was worried ab

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