thinking about adding Amlexanox to my current setup

Posted by amber464 in Weight Loss & Metabolic - 12 points, 3 comments.

i've been tracking everything for a while now and my weight loss has basically hit a wall. my steps are still okay and my HRV is stable, but the scale just isnt budging like it used to. since i'm already on a GLP-1, i've been looking into things that actually target energy expenditure instead of just killing my appetite.

i came across amlexanox /peptides/peptide-amlexanox and the idea of inhibiting those TBK1 and IKK epsilon kinases to fix insulin resistance sounds interesting. imo it makes more sense to try and restore thermogenesis than to just keep bumping up my sema dose and feeling nauseous all the time.

has anyone here actually tried this? i'm curious if it actually helps with the stubborn fat or if the GI upset is a dealbreaker. i've read the range is usually 25 to 100 mg three times a day but that seems like a lot of pills. if anyone has their own data on how it affected their energy levels or bloodwork trends i'd love to see it. i'm trying to be meticulous about the titration so i dont just crash my system.

Comments

• rationaljenna: I tried amlexanox a few months ago when my GLP‑1 plateaued, so I can share what I saw in my own numbers. I started at 25 mg once daily with food and added a second dose after lunch after two weeks; I never got to three doses because the stomach started to feel queasy each time. 5 kg for six weeks. HRV was unchanged and I felt a bit more “warm” after workouts, but the GI upset made me stop. If you decide to try, I’d keep it to two doses and watch your triglycerides and liver enzymes – they rose
• amber464: Thanks for the rundown, Jenna. The 5 kg drop in six weeks is actually pretty encouraging – I’ve only seen ~2 kg max in similar timeframes on just the GLP‑1. I’ll start with 25 mg once daily with breakfast and add the second dose after lunch if my stomach holds up, watching my TGs and ALT like you did. Any tips on timing the split doses around carbs to maybe blunt the queasiness?
• amber464: that warm feeling during workouts is interesting, maybe that's the thermogenesis actually kicking in. the 5kg in six weeks is definitely a win, but the liver enzyme spike is a red flag imo. i'm definitely gonna keep an eye on my labs if i go for it. since you felt queasy, did the nausea feel similar to the sema stuff or was it a different kind of stomach upset? i can't handle any more nausea right now.

Community discussion - research and educational context only. Not medical advice.