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Anyone running pregnenolone + progesterone together? Thinking about stacking

Posted by tyler_m in Protocols & Stacks - 5 points, 4 comments.

So ive been digging into pregnenolone for a bit, partly for the cognitive side and partly because the whole "mother hormone" thing made sense to me as a way to support my stack without just throwing more testosterone at the system. Started low, around 50mg in the morning, and honestly the sleep depth and general calm the next day felt noticeably better, though im fully aware that could just be placebo after reading too much about it.

Now im tempted to add micronized progesterone at night, maybe 100mg oral before bed. The reasoning in my head is pregnenolone upstream feeding the pathway, progesterone downstream to oppose any excess estrogen conversion and help with GABA-mediated sleep. Sounds clean on paper.

But to be fair this is where I start questioning myself. Am I just stacking hormones because theyre available, or is there a real rationale? Has anyone here actually run both together and noticed anything worthwhile, or did it turn into a mess of mood swings and weird sides? Genuinely curious what peoples bloodwork looked like before and after if youve done it.

Comments

  • fasted_scientist: Ngl this is exactly the kind of stack that sounds clever on paper but worries me a bit. Preg feeding into prog makes sense in theory, but you're messing with two hormones that both go through a lot of conversion pathways, and once they're in the system you've got DHEA, allopregnanolone, cortisol, the lot all in play. The 50mg preg dose you mentioned seems quite high to start on (most protocols I've seen start way lower), and I'd want to know what your bloodwork looked like before adding anythin
  • tyler_m: Yeah fair points across the board, to be honest your comment has me second guessing the 50mg start, i just picked that number because it was the top of what i saw in a few threads. No bloodwork yet, thats on me, i was waiting till id been on it a month to get a proper baseline before pulling anything. And youre right about the prog for E2 thing, that was me reverse engineering a justification, the E2 isnt actually high its just something i was pre empting. If you had to pick one to drop from the
  • tiredmira: Yeah the conversion mess is what worries me too honestly. Even with bloodwork it's hard to predict where it's all gonna end up. I keep my preg pretty low, like 25mg, and haven't touched prog because the downstream stuff just feels like opening a box I can't close 😅 how are you tracking it, just symptoms or actual labs?
  • tyler_m: Yeah fair point on the "opening a box" bit, thats kind of where my head is at too. Im tracking symptoms mostly, sleep notes in a little app and how i feel the next morning, but i havent pulled bloods yet on the preg alone which is a bit daft of me i know. Probably gonna get a baseline panel done before i add anything else, hormones + metabolites. Honestly if preg is doing what i think it is at 50 i might just stay there and not open that box with prog like you said 😴

Community discussion - research and educational context only. Not medical advice.