ResearchSafe

"Tirzepatide recomp stack with KLOW on the side, timing the regenerative stuff around dose day?"

Posted by grinder265 in Protocols & Stacks - 3 points, 4 comments.

Been running tirzepatide for about 4 months now, currently sitting at 7.5mg once a week and the appetite suppression is real but im also lifting heavy 5-6x a week and running 40-50 miles weekly so im paranoid about losing lean mass. Down about 22 lbs so far, bloodwork looks clean, A1c dropped nicely.

Heres what im trying to figure out. I want to add KLOW into the rotation for connective tissue support and general recovery since the training volume is high. The issue is dose day for tirz makes me pretty nauseous for 24-36 hrs and my appetite is basically zero that whole window. So when do you actually pin the regenerative stuff?

Right now im doing GHK-Cu 200mcg and TB-500 2.5mg on mon/thurs, BPC and KPV daily. I moved tirz to friday night so the nausea hits over the weekend. But friday is also a training day so im not sure if i should be stacking all that recovery signaling on top of a system thats busy dealing with GI side effects.

Anyone running a similar combo? Curious how you spaced things out and if you noticed the tirz side effects got better or worse with the KLOW pieces added in.

Comments

  • night_sleep450: Honestly the dose day nausea was the worst part for me too when I was on it, the first few months were rough til my body settled down a bit. What worked was pushing anything gut related way away from injection day, so I'd skip the BPC and KPV entirely on dose day and just restart them the next evening once I could keep food down. Imo the KLOW stuff probably won't make the nausea worse but your stomach isn't gonna absorb oral peptides well when you're actively queasy anyway, so timing wise it jus
  • grinder265: Yeah skipping the oral stuff on dose day is solid, didnt think about the absorption angle since im usually forcing down some protein shake anyway by saturday morning. BPC subq tho, you think that one matters too or just the KPV specifically? And ngl the volume comment kinda got me, you cut anything back when you were running heavy mileage on it or just pushed through the fatigue?
  • tiredmira: Yeah waiting until the next evening makes sense to me too, no point in swallowing anything if it's just gonna come back up 😅 And yeah I keep saying this to people, 40-50 miles a week on a deficit is wild. Even if the scale is going down, the cortisol and recovery cost is something bloodwork won't always show. Would love to see your HRV trend over the last few months if you have it, that's usually where it shows up first.
  • grinder265: Ngl my HRV has been pretty flat honestly, which surprised me because I figured it'd tank. Resting HR is sitting around 48-50 most mornings. Cortisol came back mid-range on my last panel which I took as a decent sign but idk, could just be noise at this point. The weekend timing is annoying but workable. I just dose everything saturday evening now once the worst of the nausea passes.

Community discussion - research and educational context only. Not medical advice.