Tirzepatide vs semaglutide, what your actual 12-week numbers looked like?

Posted by weekendnate in Weight Loss & Metabolic - 5 points, 5 comments.

Curious what other people are seeing when they compare the two head to head. I ran sema for about 9 months, hit a wall around 14% down, and switched over to tirz to see if the dual agonist thing made a real difference beyond the marketing.

For me the first 8 weeks on tirz felt almost identical to sema at the same point. Appetite suppression was there but not dramatically different. Then somewhere around week 10 the food noise dropped in a way sema never did for me. Cravings went from maybe a 4 out of 10 to basically background static.

Side effect wise, tirz hit my stomach harder during the titration steps. The 7.5 mg jump wrecked me for about 4 days. Sema was gentler going up but the constipation never really went away.

Down about 9% in 12 weeks on tirz so far, which tracks with what I had read about the early curve being similar before it separates. HRV held steady through both, sleep actually improved once the appetite noise quieted down.

Anyone else notice the divergence happening later than the trials suggest? Wondering if it's a me thing or a pattern.

Comments

• elle_z: Interesting that your experience was so close early on then split later, because my timeline looked almost flipped 😅 i went straight to tirz first, no sema background, and the food noise thing kicked in for me around week 3, not week 10. Same compounding-onto-itself feeling you're describing tho, like the first couple weeks were fine but then suddenly i was just... Not that bothered about food? Steady lah, hardest part was the 5mg step, felt gross for 3 days and then fine. Are you tracking any
• weekendnate: Week 3 is way earlier than mine, interesting. I wonder if going straight in vs coming off sema changes the ramp somehow, or if I was just slower to titrate up. Yeah I keep a spreadsheet, HRV and sleep are in there every morning, plus a weekly average weight and a quick note on how bad the side effects got at each dose step. Nothing fancy, just consistent. Sleep actually dipped on the 7.5 jump and took about a week to settle back to baseline. Did your HRV move at all or stay flat through the rou
• lifter_daily: That's interesting, the compounding thing. For me it really did feel like week 10 was a different drug to weeks 1 to 8, not just the same thing ramping up. Strange how it kicked in for you way earlier though, could be loads of things behind that. Yeah the 5mg step, cheers for reminding me, that was rough for me too. Nausea for a couple of days and then fine. Scale only tbh, I should probably be tracking waist or something but probably not.
• weekendnate: Yeah the 5mg step got me too, I had it in my head as the 7.5 because that one dragged on for almost a week. Nausea fading after a couple days sounds about right though. And yeah, I went back and looked and mine really did start separating around week 9 or 10, not as early as I remembered typing it. Weird how that works. You should track waist though, the scale lies more than people think and waist tells you a lot more about what's actually shifting.
• patient_codes: Right?? I had the same thing happen, I went back through my notes and the food noise drop was closer to week 11 for me, not the 8 I kept telling people. Memory is wild 🧠 Waist tracking is a good call though, I started doing that with a soft tape every Sunday and yeah the inches moved before the scale did. Way more useful than just watching the number honestly.

Community discussion - research and educational context only. Not medical advice.