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Mazdutide vs tirz for someone who stalled at month 4 on tirz, anyone cross-shopped?

Posted by tiredmira in Weight Loss & Metabolic - 8 points, 6 comments.

I have been on tirz since January and the first three months were honestly great, I dropped about 18 pounds and the appetite suppression felt pretty smooth. Around month 4 the scale basically froze though. I am eating in a slight deficit, lifting three times a week, walking a lot, and my weight has been bouncing in the same two pound window for almost six weeks now 😅

I have been reading about mazdutide since the dual GLP-1 and glucagon mechanism seems like it would actually do something different for stalled people like me. The hepatic fat piece is interesting too because my last bloodwork showed ALT creeping up.

For anyone who actually tried both, how did mazdutide feel compared to tirz on the appetite side? And was the GI stuff worse during titration or about the same?

I know nobody can tell me what to do here, I am just trying to get a feel for real experiences before I bring it up at my next appointment. Basically stuck between pushing my tirz dose higher or switching the whole train.

Comments

  • liam468: Appreciate you laying out the timeline, that helps a lot. I have not tried mazdutide myself so I can't speak to the switch, but the stall pattern you are describing lines up with what I have read, basically your body catches up to the caloric deficit and the med sort of plateaus with you. Have you recalculated your TDEE since you lost the 18 pounds? That is usually the first thing people miss, because the deficit you set in January is not the same deficit you need now. On the mazdutide questio
  • tired_grinder: Yeah the TDEE thing is huge, most people forget that as you drop weight you need less food so what was a deficit in January is just maintenance now? I made that same mistake once years ago when I cut without recalculating, took me a while to figure out why nothing was moving. Did you tighten up the calories or bump the cardio since the stall hit?
  • riley_p: Yeah, the TDEE thing is such an easy miss. My deficit when i started was noticeably bigger than what i actually need now, and i only caught it because i started weighing food properly again around month 3. Could just be that for you too, worth a look before switching anything. On mazdutide i have no personal experience either, but the liver fat angle is what keeps catching my eye too. Curious what your doc actually says about the dual mechanism, since that is the piece i would want a real answe
  • tiredmira: Yeah the TDEE recalibration is honestly something I probably need to do first, my calories have not changed since January and my body comp is definitely different now 😅 I have an appointment next week so I will bring up the dual mechanism and what the actual evidence is for ALT improvement at the doses being studied. I will report back what she says.
  • tiredmira: Honestly no, I just kind of kept eating the same amount because the satiety was so strong on tirz I assumed it was still doing the work 😅 Rereading your reply and yeah, the TDEE drop thing makes total sense. I dropped almost 20 pounds so my maintenance is probably a few hundred calories lower than where I started. I am going to actually log properly for a week before changing anything though. If my intake is really still at January levels that could be the whole stall right there and switchin
  • tiredmira: Yeah the TDEE recalculation is a fair point, I actually did drop my calories by about 150 a few weeks in but not since then. Probably due for another look. The stall feels different from just slower loss though, like the appetite suppression itself has kind of mellowed too. Same dose, same shot day, just less of that "I forgot to eat" feeling I had early on. I have an appointment next week so I will bring up mazdutide and the liver numbers together, my ALT was 42 last draw which my doc already

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