topol on peptides, finally someone saying the quiet part out loud
Posted by aspiringruby in GH & Growth Peptides - 30 points, 6 comments.
read topol's latest and honestly felt seen? he's not wrong about the data gaps, like literally zero long term safety studies on any of this stuff and we're all running around acting like it's settled science? as a pt i see people stacking cjc/ipamorelin like it's a multivitamin and nobody knows what happens at month eighteen? the mk-677 cortisol prolactin thing tracks with what i've seen in bloods too, had a guy whose prolactin doubled in six weeks and nobody warned him? the compounding pharmacy crackdown was inevitable tbh you can't sell research chems as therapy forever? my own experience with sermorelin was fine sleep improved maybe body comp barely moved but that's anecdote not evidence? the hype to evidence ratio is just wild right now
what's the longest anyone here has run a secretagogue with actual lab follow up? genuinely curious if anyone's tracking markers past the six month mark?
Comments
- honest_macros: yeah, that’s the part people skip way too fast. the hype is ahead of the evidence, and not gonna lie, the lack of clean long-term data is the main reason i stay cautious with secretagogues. i’ve seen the same thing in practice, people talk about cjc/ipamorelin like it’s vitamins, then get surprised when labs start moving in ways they did not expect. for me, sermorelin felt mild, sleep maybe a bit better, but that was just my own experience and could be placebo. six months with actual follow-up
- ironman_lifter: Same here, sir. Fwiw, the “it’s just a little peptide” talk gets people into trouble because the labs can move quietly first, then everyone acts shocked later. Sermorelin was pretty underwhelming for me too, maybe a bit better sleep, but nothing dramatic. If someone has real follow-up beyond a few weeks, that is the part I would trust more.
- practical_coldplunge: Totally with you – I’ve also found the hype far outpaces the data, so I’m extra careful with secretagogues. My own six‑month trial of ipamorelin gave me a tiny boost in recovery but my fasting glucose barely budged, and my prolactin crept up a notch, so I keep checking labs every couple of months.
- aspiringruby: that prolactin creep is exactly what i'm talking about? it's so subtle until you actually see the numbers? for me, the sermorelin didn't hit my prolactin, but the sleep gain was the only real win. since you're checking labs every couple of months, are you tracking hba1c or just fasting glucose? i'm curious if a longer run actually changes the glucose trend or if it just plateaus?
- aspiringruby: yeah exactly? the "little peptide" thing is a dangerous mindset. it's why i'm so obsessive about my logs. it's funny we both felt the same on sermorelin. for me it was just a slight bump in sleep quality and then nothing? didn't see those dramatic shifts people talk about. i'm still hunting for someone who actually did long term bloods though. did you track your fasting glucose or insulin while you were on it? that's the part i'm most worried about long term?
- aspiringruby: i hear you on the glucose thing – i actually ran sermorelin for about 7 months and did a fasting glucose and HbA1c at month 4 and again at month 7. 2 %). i also tracked IGF‑1, which dipped a tiny bit after the first two months then leveled out. not a huge change but at least i have data past the six‑month mark. did you happen to see any shifts in lipid panels or thyroid numbers in your own six‑month runs?
Community discussion - research and educational context only. Not medical advice.