ResearchSafe

Retatrutide Phase 3 numbers look strong, but the side effect profile is what I'd watch

Posted by tiredmira in Weight Loss & Metabolic - 12 points, 3 comments.

https://www.clinicaltrialsarena.com/news/eli-lilly-retatrutide-phase-iii-triumph-1-study-results

Clinical Trials Arena had a good breakdown of the TRIUMPH-1 data. Highest dose group lost about 28% of body weight at 80 weeks, which honestly is wild on paper. That's basically in the same neighborhood as what people see with bariatric surgery, so the headlines aren't exaggerating that part.

The thing that stood out to me though is the AE chatter. Analysts seem uneasy about the side effect profile, and Lilly's own data still points to a lot of GI stuff like nausea. For me that matters more than the average weight loss number, because averages don't tell you what the worst weeks actually feel like.

If you've been on a GLP-1 or dual agonist already, how are you thinking about whether the extra efficacy is worth a potentially rougher ride? Genuinely curious how people would weigh that tradeoff.

Comments

  • runner_aaron: That 28% number is genuinely nuts, no argument. But yeah, the GI side of things is what would make me pause before jumping up to the highest dose if I ever tried it. I did a tirz run earlier this year and the nausea weeks were rougher than I expected. Functional, but I basically had to plan my food around it and there were a couple evenings I just didn't eat. For me that tradeoff gets real once it starts messing with training recovery, not so much when it's just uncomfortable. How are you thin
  • tiredmira: Honestly that's exactly the line I keep coming back to, when it starts eating into recovery and training volume it stops being a math problem and starts being a quality of life one. For me slow titration is the default, I'd probably push every step out an extra week past what Lilly suggests just to see how I tolerate each dose before going up. The data on slower ramps showing better adherence kind of confirms what people anecdotally report, so why not lean into it 😅
  • tiredmira: Slower ramp 100%, my cut-off right now would be doubling the interval on whatever Lilly suggests as the starting schedule. Basically for me the deciding factor isn't the peak dose, it's how fast I can get there without my sleep tanking or my HRV dropping off. The GI stuff usually follows the jumps, so spacing them out longer just gives your body time to settle. Also I'd probably cap where I go based on what my bloodwork and weight trend look like at each step, not push to the top just because

Community discussion - research and educational context only. Not medical advice.